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Neuromodulatory activity in neocortex changes with behavioral state, affecting cortical information processing. For example, in mouse visual cortex the responsiveness of pyramidal neurons to visual input is enhanced during motor activity. Changes in cortical function with motor activity, and also likely changes arousal and attentional states, are driven, at least in part, by the neuromodulators released into cortex, but when the many different neuromodulatory pathways active and how does each affect cortical neurons? I will discuss our efforts to monitor the activities of cholinergic, noradrenergic and serotoninergic axons in visual cortex during visual detection and discrimination tasks, using imaging approaches and various Allen Institute mouse lines to drive expression of GCaMP calcium indicators in neuromodulatory axons.
Free
Contact:
Candace Burke | cj.burke@uleth.ca