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Mechanisms underlying recovery from early cortical injury in rats

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author Dallison, Agnes
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-04-24T19:47:26Z
dc.date.available 2007-04-24T19:47:26Z
dc.date.issued 1999
dc.identifier.uri http://hdl.handle.net/10133/98
dc.description viii, 74 leaves : col. ill. ; 28 cm. en
dc.description.abstract Previous work has shown that removal of the midline frontal cortex at seven to ten days of age is followed by recovery of function correlated with apparent spontaneous generation of new tissue in the lesion cavity. The question asked in the present thesis was whether the removal of the regrown tissue in adulthood would block normal function. Rats that received P10 frontal lesions underwent second lesions at P160, and were compared to rats with only P10 or P160 lesions. Rats with P10 + P160 lesions were severely impaired on a spatial learning task, especially relative to the P10 lesion-only rats. In a second experiment, rats with P10 + P160 lesions were given intra-ventricular infusions of a cocktail of three growth factors. The animals with growth factors showed marked behavioral recovery, although there was no cell regeneration. The results of these experiments suggest that filled-in tissue in neonatally lesioned rats is functional. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1999 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Brain -- Wounds and injuries en
dc.subject Rats as laboratory animals en
dc.subject Animal intelligence en
dc.subject Dissertations, Academic en
dc.title Mechanisms underlying recovery from early cortical injury in rats en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience


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