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Neural changes in forelimb cortex and behavioural development

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dc.contributor.advisor Whishaw, Ian
dc.contributor.author Coles, Brenda Louise Kay
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-04-20T21:54:52Z
dc.date.available 2007-04-20T21:54:52Z
dc.date.issued 1996
dc.identifier.uri http://hdl.handle.net/10133/85
dc.description x, 132 leaves : ill. ; 28 cm. en
dc.description.abstract Neural changes in the forelimb cortex were studied at Postnatal (P) 10, 15, 20, 25, 30, and 100 days. Six biological markers of brain development, cortical thickness, Layer III pyramidal cell morphology, glial fibrillary acidic protein (GFAP), myelination, c-fos activity and Acetylcholinesterase (AChE) were correlated with the behavioural development of reaching, bimanual coordination, postural adjustment, and defensive feeding behaviours. The behaviours were filmed from P15 until P30 and then also in adulthood. For the behaviours there was a gradual development of the skilled patterns of paw and digit use seen in adults as well as in the patterns of movements in postural adjustment, carry behaviours and dodging and robbing type behaviours. The development of the adult patterns of movement were correlated to the morphological and biochemical changes in the cortex. The results suggest that the maturation of skilled movements depends upon anatomical and neurochemical maturation of the neocortex as well as upon learning. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1996 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Prefrontal cortex en
dc.subject Developmental psychology en
dc.subject Rodents -- Physiology en
dc.subject Rats as laboratory animals en
dc.subject Dissertations, Academic en
dc.title Neural changes in forelimb cortex and behavioural development en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Psychology

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