Browsing Faculty Research and Publications by Author "Kovalchuk, Igor"

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  • Maheshwari, Priti; Kovalchuk, Igor (Frontiers MediaArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2016)
    The present study demonstrates Agrobacterium tumefaciens-mediated stable genetic transformation of two species of poplar – Populus angustifolia and Populus balsamifera. The binary vector pCAMBIA-Npro-long-Luc containing ...
  • Yao, Youli; Robinson, Alexandra M.; Zucchi, Fabiola C. R.; Robbins, Jerrah C.; Babenko, Olena M.; Kovalchuk, Olga; Kovalchuk, Igor; Olson, David M.; Metz, Gerlinde A. S. (BioMed CentralArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeUniversity of Alberta, 2014)
    Abstract Background: Chronic stress is considered to be one of many causes of human preterm birth (PTB), but no direct evidence has yet been provided. Here we show in rats that stress across generations has downstream ...
  • Bilichak, Andriy; Ilnytskyy, Yaroslav; Woycicki, Rafal; Kepeshchuk, Nina; Fogen, Dawson; Kovalchuk, Igor (Frontiers MediaArts and ScienceDepartment of Biological SciencesLethbridge Research CentreUniversity of Lethbridge, 2015)
    Plants are able to maintain the memory of stress exposure throughout their ontogenesis and faithfully propagate it into the next generation. Recent evidence argues for the epigenetic nature of this phenomenon. Small RNAs ...
  • Migicovsky, Zoë; Kovalchuk, Igor (Frontiers MediaArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2012)
    Angiosperms do not contain a distinct germline, but rather develop gametes from game-tophyte initials that undergo cell division.These gametes contain cells that give rise to an endosperm and the embryo. DNA methylation ...
  • Babenko, Olena; Golubov, Andrey; Ilnytskyy, Yaroslav; Kovalchuk, Igor; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of Biological SciencesCanadian Centre for Behavioural NeuroscienceUniversity of LethbridgeUniversity of Calgary, 2012)
    Stress represents a critical influence on motor system function and has been shown to impair movement performance. We hypothesized that stress-induced motor impairments are due to brain-specific changes in miRNA and ...
  • Kovalchuk, Igor; Walz, Paul; Thomas, James; Kovalchuk, Olga (Public Library of ScienceArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2013)
    Bacterial infection has been linked to carcinogenesis, however, there is lack of knowledge of molecular mechanisms that associate infection with the development of cancer. We analyzed possible effects of the consumption ...
  • Zucchi, Fabiola C. R.; Yao, Youli; Ilnytskyy, Yaroslav; Robbins, Jerrah C.; Soltanpour, Nasrin; Kovalchuk, Igor; Kovalchuk, Olga; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeUniversity of Mato Grosso State, 2014)
    Prenatal stress (PS) represents a critical variable affecting lifetime health trajectories, metabolic and vascular functions. Beneficial experiences may attenuate the effects of PS and its programming of health outcomes ...
  • Zucchi, Fabiola C. R.; Yao, Youli; Ward, Isaac D.; Ilnytskyy, Yaroslav; Olson, David M.; Benzies, Karen; Kovalchuk, Igor; Kovalchuk, Olga; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceDepartment of Biological SciencesUniversity of LethbridgeUniversity of Mato Grosso StateUniversity of AlbertaUniversity of Calgary, 2013)
    The gestational state is a period of particular vulnerability to diseases that affect maternal and fetal health. Stress during gestation may represent a powerful influence on maternal mental health and offspring brain ...
  • Byeon, Boseon; Kovalchuk, Igor (Public Library of ScienceArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2016)
    The usefulness and the utility of the next generation sequencing (NGS) technology are based on the assumption that the DNA or cDNA cleavage required to generate short sequence reads is random. Several previous reports ...
  • Bilichak, Andriy; Ilnytskyy, Yaroslav; Hollunder, Jens; Kovalchuk, Igor (Public Library of ScienceArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeGhent University, 2012)
    Plants are able to acclimate to new growth conditions on a relatively short time-scale. Recently, we showed that the progeny of plants exposed to various abiotic stresses exhibited changes in genome stability, methylation ...
  • Ziemienowicz, Alicja; Seyed Mohammad, Reza Rahavi; Kovalchuk, Igor (Korean Society for Biochemistry and Molecular BiologyArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2011)
    The single-stranded DNA binding activity of the Escherichia coli RecA protein is crucial for homologous recombination to occur. This and other biochemical activities of ssDNA binding proteins may be affected by various ...
  • Yao, Youli; Kathiria, Palak; Kovalchuk, Igor (Frontiers MediaArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2013)
    In the past, we showed that loca linfection of tobacco leaves with either tobacco mosaic virus or oilseed rape mosaic virus (ORMV) resulted in a systemic increase in the homologous recombination frequency (HRF). Later on, ...
  • Boyko, Alex; Blevins, Todd; Yao, Youli; Golubov, Andrey; Bilichak, Andriy; Ilnytskyy, Yaroslav; Hollunder, Jens; Meins, Frederick; Kovalchuk, Igor (Public Library of ScienceArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeFriedrich Miescher Institute for Biomedical ResearchGhent University, 2010)
    Epigenetic states and certain environmental responses in mammals and seed plants can persist in the next sexual generation. These transgenerational effects have potential adaptative significance as well as medical and ...
  • Rahavi, Mohammad Reza; Migicovsky, Zoë; Titov, Viktor; Kovalchuk, Igor (Frontiers MediaArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2011)
    Exposure to abiotic and biotic stress results in changes in plant physiology and triggers genomic instability. Recent reports suggest that the progeny of stressed plants also exhibit changes in genome stability, stress ...
  • Boyko, Alexander; Kathiria, Palak; Zemp, Franz J.; Yao, Youli; Pogribny, Igor; Kovalchuk, Igor (Oxford University PressArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeNational Center for Toxicological Research, 2007)
    Previously, we reported the generation of a virusinduced systemic signal that increased the somatic and meiotic recombination rates in tobacco mosaic virus (TMV)-infected tobacco plants. Here, we analyzed the progeny ...
  • Kovalchuk, Igor; Kovalchuk, Olga (M D P I A GArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2008)
    Rapid technological development is inevitably associated with many environmental problems which primarily include pollution of soil, water and air. In many cases, the presence of contamination is difficult to assess. It ...

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