Faculty Research and Publications

Recent Submissions

  • Krishnan, Preethi; Ghosh, Sunita; Wang, Bo; Heyns, Mieke; Li, Dongping; Mackey, John R.; Kovalchuk, Olga; Damaraju, Sambasivarao (Nature Publishing GroupArts and ScienceDepartment of Biological SciencesUniversity of AlbertaCross Cancer InstituteUniversity of Lethbridge, 2016)
    Transfer RNAs (tRNAs, key molecules in protein synthesis) have not been investigated as potential prognostic markers in breast cancer (BC), despite early findings of their dysregulation and diagnostic potential. We aim ...
  • Krishnan, Preethi; Ghosh, Sunita; Wang, Bo; Li, Dongping; Narasimhan, Ashok; Berendt, Richard; Graham, Kathryn; Mackey, John R.; Kovalchuk, Olga; Damaraju, Sambasivarao (BioMed CentralArts and ScienceDepartment of Biological SciencesUniversity of AlbertaCross Cancer InstituteUniversity of Lethbridge, 2015)
    Background: Prognostication of Breast Cancer (BC) relies largely on traditional clinical factors and biomarkers such as hormone or growth factor receptors. Due to their suboptimal specificities, it is challenging to ...
  • Hudson, Andrew J.; Moore, Ashley N.; Elniski, David; Joseph, Joella; Yee, Janet; Russell, Anthony G. (Oxford University PressArts and ScienceDepartment of Biological SciencesAlberta RNA Research and Training InstituteUniversity of LethbridgeTrent University, 2012)
    Non-coding RNAs (ncRNAs) have diverse essential biological functions in all organisms, and in eukaryotes, two such classes of ncRNAs are the small nucleolar (sno) and small nuclear (sn) RNAs. In this study, we have ...
  • Costa, Estela; Uwiera, Richard R. E.; Kastelic, John P.; Selinger, L. Brent; Inglis, G. Douglas (BioMed CentralArts and ScienceDepartment of Biological SciencesLethbridge Research CentreUniversity of LethbridgeUniversity of Alberta, 2011)
    Background: The development of efficacious alternatives to antimicrobial growth promoters (AGP) in livestock production is an urgent issue, but is hampered by a lack of knowledge regarding the mode of action of AGP. ...
  • Ziemienowicz, Alicja; Seyed Mohammad, Reza Rahavi; Kovalchuk, Igor (Korean Society for Biochemistry and Molecular BiologyArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2011)
    The single-stranded DNA binding activity of the Escherichia coli RecA protein is crucial for homologous recombination to occur. This and other biochemical activities of ssDNA binding proteins may be affected by various ...
  • Hauer, F. Richard; Locke, Harvey; Dreitz, Victoria J.; Hebblewhite, Mark; Lowe, Winsor H.; Muhfield, Clint C.; Nelson, Cara R.; Proctor, Michael F.; Rood, Stewart B. (American Association for the Advancement of ScienceArts and ScienceDepartment of Biological SciencesUniversity of MontanaUniversity of Lethbridge, 2016)
    Gravel-bed river floodplains in mountain landscapes disproportionately concentrate diverse habitats, nutrient cycling, productivity of biota, and species interactions. Although stream ecologists know that river channel ...
  • Beck, Melissa A.; Colwell, Douglas D.; Goater, Cameron P.; Kienzle, Stefan W. (Biomed Central LtdArts and ScienceDepartment of Biological SciencesDepartment of GeographyUniversity of LethbridgeLethbridge Research Centre, 2015)
    Background: Gastrointenstinal nematodes (GIN) present a serious challenge to the health and productivity of grazing stock around the globe. However, the epidemiology of GIN transmission remains poorly understood in northern ...
  • Alexander, Trevor W.; Yanke, Jay L.; Reuter, Tim; Topp, Ed; Read, Ronald R.; Selinger, L. Brent; McAllister, Tim A. (Biomed Central LtdArts and ScienceDepartment of Biological SciencesUniversity of VermontLethbridge Research CentreAgriculture and Agri-Food Research Centre (Ont.)University of CalgaryUniversity of Lethbridge, 2011)
    Background: Environmental transmission of antimicrobial-resistant bacteria and resistance gene determinants originating from livestock is affected by their persistence in agricultural-related matrices. This study investigated ...
  • Munns, Krysty D.; Zaheer, Rahat; Xu, Yong; Stanford, Kim; Laing, Chad R.; Gannon, Victor P. J.; Selinger, L. Brent; McAllister, Tim A. (Public Library of ScienceArts and ScienceDepartment of Biological SciencesLethbridge Research CentreUniversity of LethbridgeAgriculture and ForestryPublic Health Agency of Canada, 2016)
    Cattle are the primary reservoir of the foodborne pathogen Escherichia coli O157:H7, with the concentration and frequency of E. coli O157:H7 shedding varying substantially among individual hosts. The term ‘‘super-shedder” ...
  • Lone, Abdul G.; Selinger, L. Brent; Uwiera, Richard R. E.; Xu, Yong; Inglis, G. Douglas (Public Library of ScienceArts and ScienceDepartment of Biological SciencesLethbridge Research CentreUniversity of LethbridgeUniversity of Alberta, 2013)
    Background: Campylobacter jejuni causes enterocolitis in humans, but does not incite disease in asymptomatic carrier animals. To survive in the intestine, C. jejuni must successfully compete with the microbiota and overcome ...
  • Laing, Chad R.; Zhang, Yongxiang; Gilmour, Matthew W.; Allen, Vanessa; Johnson, Roger; Thomas, James E.; Gannon, Victor P. (Public Library of ScienceArts and ScienceDepartment of Biological SciencesPublic Health Agency of CanadaOntario Agency for Health Protection and PromotionUniversity of Lethbridge, 2012)
    Escherichia coli O104:H4 was associated with a severe foodborne disease outbreak originating in Germany in May 2011. More than 4000 illnesses and 50 deaths were reported. The outbreak strain was a typical enteroaggregative ...
  • Gruninger, Robert J.; Thibault, John; Capeness, Michael J.; Till, Robert; Mosimann, Steven C.; Sockett, R. Elizabeth; Selinger, L. Brent; Lovering, Andrew L. (Public Library of ScienceArts and ScienceDepartment of Biological SciencesDepartment of Chemistry and BiochemistryLethbridge Research and Development CentreUniversity of NottinghamUniversity of LethbridgeUniversity of Birmingham, 2014)
    Bdellovibrio bacteriovorus is an unusual d-proteobacterium that invades and preys on other Gram-negative bacteria and is of potential interest as a whole cell therapeutic against pathogens of man, animals and crops. PTPs ...
  • Kovalchuk, Anna; Mychasiuk, Richelle; Muhammad, Arif; Hossain, Shakhawat; Ilnytskyy, Yaroslav; Ghose, Abhijit; Kirkby, Charles; Ghasroddashti, Esmaeel; Kolb, Bryan; Kovalchuk, Olga (Frontiers MediaArts and ScienceDepartment of NeuroscienceDepartment of Biological SciencesUniversity of LethbridgeAlberta Epigenetics NetworkUniversity of CalgaryAlberta Health ServicesCanadian Institute for Advanced Research, 2016)
    Irradiated cells can signal damage and distress to both close and distant neighbors that have not been directly exposed to the radiation (naïve bystanders). While studies have shown that such bystander effects occur in the ...
  • Zucchi, Fabiola C. R.; Yao, Youli; Ward, Isaac D.; Ilnytskyy, Yaroslav; Olson, David M.; Benzies, Karen; Kovalchuk, Igor; Kovalchuk, Olga; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceDepartment of Biological SciencesUniversity of LethbridgeUniversity of Mato Grosso StateUniversity of AlbertaUniversity of Calgary, 2013)
    The gestational state is a period of particular vulnerability to diseases that affect maternal and fetal health. Stress during gestation may represent a powerful influence on maternal mental health and offspring brain ...
  • Boyko, Alexander; Kathiria, Palak; Zemp, Franz J.; Yao, Youli; Pogribny, Igor; Kovalchuk, Igor (Oxford University PressArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeNational Center for Toxicological Research, 2007)
    Previously, we reported the generation of a virusinduced systemic signal that increased the somatic and meiotic recombination rates in tobacco mosaic virus (TMV)-infected tobacco plants. Here, we analyzed the progeny ...
  • Yao, Youli; Kathiria, Palak; Kovalchuk, Igor (Frontiers MediaArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2013)
    In the past, we showed that loca linfection of tobacco leaves with either tobacco mosaic virus or oilseed rape mosaic virus (ORMV) resulted in a systemic increase in the homologous recombination frequency (HRF). Later on, ...
  • Migicovsky, Zoë; Kovalchuk, Igor (Frontiers MediaArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2012)
    Angiosperms do not contain a distinct germline, but rather develop gametes from game-tophyte initials that undergo cell division.These gametes contain cells that give rise to an endosperm and the embryo. DNA methylation ...
  • Rahavi, Mohammad Reza; Migicovsky, Zoë; Titov, Viktor; Kovalchuk, Igor (Frontiers MediaArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2011)
    Exposure to abiotic and biotic stress results in changes in plant physiology and triggers genomic instability. Recent reports suggest that the progeny of stressed plants also exhibit changes in genome stability, stress ...
  • Maheshwari, Priti; Kovalchuk, Igor (Frontiers MediaArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2016)
    The present study demonstrates Agrobacterium tumefaciens-mediated stable genetic transformation of two species of poplar – Populus angustifolia and Populus balsamifera. The binary vector pCAMBIA-Npro-long-Luc containing ...
  • Bilichak, Andriy; Ilnytskyy, Yaroslav; Woycicki, Rafal; Kepeshchuk, Nina; Fogen, Dawson; Kovalchuk, Igor (Frontiers MediaArts and ScienceDepartment of Biological SciencesLethbridge Research CentreUniversity of Lethbridge, 2015)
    Plants are able to maintain the memory of stress exposure throughout their ontogenesis and faithfully propagate it into the next generation. Recent evidence argues for the epigenetic nature of this phenomenon. Small RNAs ...

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