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Does one plus one make two? Investigation of pharmacological effects and cortical injury on the developing brain

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author van Waes, Linda T. A
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2009-10-13T15:46:00Z
dc.date.available 2009-10-13T15:46:00Z
dc.date.issued 2009
dc.identifier.uri http://hdl.handle.net/10133/782
dc.description xii, 169 leaves : ill. ; 29 cm. en
dc.description.abstract This thesis examined how pharmacological treatment and cortical injury during development affects brain plasticity. Rats were given either a low dose of perinatal fluoxetine or a mild postnatal day 7 Hypoxic‐Ischemic (HI) injury, both, or neither. The functional outcome was assessed using a series of behavioral tasks and anatomical measures. To assess how HI affects the development of motor maps, forelimb motor maps were evoked at P19. The findings indicate that fluoxetine treatment or HI injury mostly negatively affected functional outcome. The combined treatment with fluoxetine and HI injury only interacted on a limited number of measures. There was no delay in the emergence of evoked motor movements, or change in map location in the HI animals. These results suggest that the pharmacological treatment and cortical injury described in this thesis may have different mechanisms whereby plastic changes are induced and the interaction between these two mechanisms is limited. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Deptartment of Neuroscience, 2008 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Brain -- Wounds and injuries -- Research en
dc.subject Cerebrovascular disease -- Research en
dc.subject Brain -- Effect of drugs on en
dc.subject Rats as laboratory animals en
dc.subject Dissertations, Academic en
dc.subject Electronic dissertations en
dc.title Does one plus one make two? Investigation of pharmacological effects and cortical injury on the developing brain en
dc.type Thesis en
dc.publisher.faculty Arts and Science en
dc.publisher.department Neuroscience en

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