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dc.contributor.supervisor Sutherland, Robert J.
dc.contributor.supervisor Metz, Gerlinde A. S. Faraji, Jamshid University of Lethbridge. Faculty of Arts and Science 2009-07-07T20:50:44Z 2009-07-07T20:50:44Z 2008
dc.description xii, 252 leaves : ill. ; 29 cm. -- en
dc.description.abstract Stress-related cognitive changes are still a matter of debate. In some particular neuropathological conditions such as focal ischemia, cognitive functions have been shown to be significantly impaired. These conditions, however, may be improved by some factors such as steroid hormones. The purpose of the current thesis was to assess the structural and functional effects of corticosterone-related experiences on the hippocampus before and after endothelin-1 (ET-1)-induced stroke. We found corticosterone-related experiences enhance the hippocampal recovery, and improve its function in both wet and dryland tasks after ET-1-induced focal stroke. Structural and functional effects of such experiences prior to the focal ischemia in the hippocampus, however, showed that stress, not corticosterone is a strong inhibitor for hippocampal recovery. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta : University of Lethbridge, Faculty of Arts and Science, 2008 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Cerebrovascular disease -- Research en
dc.subject Cerebrovascular disease -- Animal models en
dc.subject Spatial behavior in animals -- Research en
dc.subject Brain -- Research en
dc.subject Hippocampus (Brain) -- Physiology en
dc.subject Rats as laboratory animals en
dc.subject Stress (Physiology) -- Research en
dc.subject Rats -- Effect of stress on en
dc.title Structural alterations in the hippocampus and spatial behavior by stress in male and female rats : protections, and recovery in water-based and dry-land tasks en
dc.type Thesis en
dc.publisher.faculty Arts and Science en
dc.publisher.department Neuroscience en Doctor of Philosophy Neuroscience
dc.organization University of Lethbridge
dc.organization University of Lethbridge
dc.librarysymbol ALU Arts and Science Sciences

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