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Early unilateral olfactory bulb lesion results in diffuse changes in behavior and overall cortical organization

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author Goldsbury, Robin Paulette
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2008-10-27T17:39:20Z
dc.date.available 2008-10-27T17:39:20Z
dc.date.issued 2007
dc.identifier.uri http://hdl.handle.net/10133/683
dc.description xix, 195 leaves : ill. (some col.) ; 29 cm. en
dc.description.abstract The current work explores the behavioural and anatomical consequences of unilateral neonatal bulbectomy (OBX) in male and female rats at postnatal day 1 (PI) and P10. In adulthood the animals underwent a battery of motor and cognitive tests, and diffuse effects of early brain injury on the development of behavior were found. Disturbing olfactory sense input during development affected motor output. Rats normally display an equal distribution of right or left paw preference. In this study, both OBX sexes showed a shifted paw preference to the ipsilesional side, and forelimb deficits were found in a skilled reaching task. Lesion animals also showed enhanced performance on a visually driven spatial cognitive test. Cross-modal compensatory changes may be responsible. Morphological changes within the cerebral cortex are described, including bulbar changes, enlarged but fewer glomeruli, smaller accessory olfactory bulb, decreased downstream connectivity, and a rostral shift of the forebrain toward the olfactory bulb. Changes to the lateral cortex were found in both intact and lesion hemispheres, along with dendritic changes in the forelimb reaching area. Cellular regeneration within the lesion bulb was indicated. Changed shape and relative size increases compared to the intact bulb were found. BrdU labeling showed increased mitotic activity in P10 lesion animals. These findings demonstrate that the impact of olfactory injury during early development goes well beyond odor perception and discrimination, and that olfactory inputs during development significantly contribute to the development of the neocortex. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Electronic dissertations en
dc.subject Brain -- Research en
dc.subject Brain -- Wounds and injuries en
dc.subject Rhinencephalon en
dc.subject Rats as laboratory animals en
dc.title Early unilateral olfactory bulb lesion results in diffuse changes in behavior and overall cortical organization en
dc.type Thesis en
dc.publisher.faculty Arts and Science en
dc.publisher.department Department of Neuroscience en

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