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Multiple-object memory requires the hippocampus

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dc.contributor.advisor Whishaw, Ian
dc.contributor.author Yim, Tonia Tan-Ling
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2008-09-26T14:58:44Z
dc.date.available 2008-09-26T14:58:44Z
dc.date.issued 2007
dc.identifier.uri http://hdl.handle.net/10133/678
dc.description vii, 150 leaves : ill. ; 29 cm. -- en
dc.description.abstract This thesis investigates the role of the hippocampus in object memory. Currently, the role of the hippocampus in object recognition is unclear, with some studies demonstrating a delay-dependent impairment after hippocampal damage, others showing no impairment. The present thesis used the novel object recognition task and its variants to investigate various types of object memory in hippocampal lesion rats. In the first study, impairments were observed in discriminating object order and associating objects with contexts, while no impairment was observed in novel object recognition. In the second study, it was found that encountering another object shortly prior to or after encountering a target object impairs the recognition of the target object. In a control procedure, encountering a novel context either shortly before or after encountering the target object did not impair object recognition. In sum, in the absence of the hippocampus, object memory becomes vulnerable to interference, rendering rats unable to discern memories of multiple objects. The present thesis concludes that the hippocampus discriminates multiple objects via pattern separation. A stimulus-response model relating the role of the hippocampus to object memory is proposed. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Brain -- Research en
dc.subject Memory -- Research en
dc.subject Hippocampus (Brain) -- Physiology -- Research en
dc.subject Electronic dissertations en
dc.subject Rats as laboratory animals en
dc.title Multiple-object memory requires the hippocampus en
dc.type Thesis en
dc.publisher.faculty Arts and Science en
dc.publisher.department Department of Neuroscience en

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