Neuroscience

 

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  • Karl, Jenni M.; Whishaw, Ian Q. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2013)
    The Dual Visuomotor Channel Theory proposes that manual prehension consists of two temporally integrated movements, each subserved by distinct visuomotor pathways in occipitoparietofrontal cortex. The Reach is mediated ...
  • Morris, Renee; Whishaw, Ian Q. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2016)
    Spinal cord injury and repair is a dynamic field of research. The development of reliable animal models of traumatic spinal cord injury has been invaluable in providing a wealth of information regarding the pathological ...
  • Morris, Renee; Whishaw, Ian Q. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2015)
    [No abstract available]
  • Thomas, Brittany L.; Karl, Jenni M.; Whishaw, Ian Q. (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2015)
    The Dual Visuomotor Channel Theory proposes that visually guided reaching is a composite of movements, a Reach that advances the hand to contact the target and a Grasp that shapes the digits for target purchase. The theory ...
  • Sparks, Fraser T.; Lehmann, Hugo; Hernandez, Khadaryna; Sutherland, Robert J. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeTrent University, 2011)
    Damage to the hippocampus (HPC) using the excitotoxin N-methyl-D-aspartate (NMDA) can cause retrograde amnesia for contextual fear memory. This amnesia is typically attributed to loss of cells in the HPC. However, NMDA ...
  • Sacrey, Lori-Ann R.; Clark, Callie A. M.; Whishaw, Ian Q. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2009)
    Parkinson’s disease (PD) results in movement and sensory impairments that can be reduced by familiar music. At present, it is unclear whether the beneficial effects of music are limited to lessening the bradykinesia of ...
  • Nie, Yimin; Fellous, Jean-Marc; Tatsuno, Masami (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of Arizona, 2014)
    The characterization of functional network structures among multiple neurons is essential to understanding neural information processing. Information geometry (IG),a theory developed for investigating a space of probability ...
  • Gomez-Lopez, Nardhy; Tanaka, Satomi; Zaeem, Zoya; Metz, Gerlinde A. S.; Olson, David M. (Biomed Central LtdArts and ScienceDepartment of NeuroscienceUniversity of AlbertaUniversity of Lethbridge, 2013)
    Background: Parturition has been widely described as an immunological response; however, it is unknown how this is triggered. We hypothesized that an early event in parturition is an increased responsiveness of ...
  • Navratilova, Zaneta; Hoang, Lan T.; Schwindel, C. Daniela; Tatsuno, Masami; McNaughton, Bruce L. (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of Arizona, 2012)
    When rodents engage in irregular foraging in an open-field environment, hippocampal principal cells exhibit place-specific firing that is statistically independent of the direction of traverse through the place field. ...
  • Akaho, Shotaro; Higuchi, Sho; Iwasaki, Taishi; Hino, Hideitsu; Tatsuno, Masami; Murata, Noboru (IOP Publishing, 2016)
    We propose a method to extract connectivity between neurons for extracellularly recorded multiple spike trains. The method removes pseudo-correlation caused by propagation of information along an indirect pathway, and ...
  • Lansink, Carien S.; Goltstein, Pieter M.; Lankelma, Jan V.; McNaughton, Bruce L.; Pennartz, Cyriel M. A. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of AmsterdamUniversity of Lethbridge, 2009)
    Associating spatial locations with rewards is fundamental to survival in natural environments and requires the integrity of the hippocampus and ventral striatum. In joint multineuron recordings from these areas, ...
  • Holec, Victoria; Pirot, Heather L.; Euston, David R. (Frontiers Research FoundationsArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    The rat anterior cingulate cortex (ACC) mediates effort-based decision making when the task requires the physical effort of climbing a ramp. Normal rats will readily climb a barrier leading to high reward whereas rats ...
  • Molina, Leonardo A.; Skelin, Ivan; Gruber, Aaron J. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    Antagonists of N-methyl-D-aspartate receptors (NMDAR) have psychotomimetic effects in humans and are used to model schizophrenia in animals. We used high-density electrophysiological recordings to assess the effects of ...
  • Christie, Gregory J.; Cook, Charles M.; Ward, Brian J.; Tata, Matthew S.; Sutherland, Janice; Sutherland, Robert J.; Saucier, Deborah M. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeSimon Fraser UniversityUniversity of Ontario Institute of Technology, 2013)
    This study investigated how both sex and individual differences in a mental rotation test (MRT) influence performance on working memory (WM). To identify the neural substrate supporting these differences, brain electrical ...
  • Proft, Juliane; Faraji, Jamshid; Robbins, Jerrah C.; Zucchi, Fabiola C. R.; Zhao, Xiaoxi; Metz, Gerlinde A. S.; Braun, Janice E. A. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of CalgaryUniversity of LethbridgeGolestan University of Medical Sciences, 2011)
    Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra and the aggregation of a-synuclein into Lewy bodies. Existing therapies address motor ...
  • Metzler, Megan J.; Saucier, Deborah M.; Metz, Gerlinde A. S. (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of Ontario Institute of Technology, 2013)
    Aging is associated with deterioration of skilled manual movement. Specifically, aging corresponds with increased reaction time, greater movement duration, segmentation of movement, increased movement variability, and ...
  • Faraji, Jamshid; Soltanpour, Nabiollah; Moeeini, Reza; Roudaki, Shabnam; Soltanpour, Nasrin; Abdollahi, Ali-Akbar; Metz, Gerlinde A. S. (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeGolestan University of Medical SciencesBabol University of Medical SciencesAvicenna Institute of Neuroscience, 2014)
    Silent focal ischemic mini infarcts in the brain are thought to cause no clinically overt symptoms. Some populations of hippocampal cells are particularly sensitive to ischemic events, however, rendering hippocampal ...
  • Kovalchuk, Anna; Mychasiuk, Richelle; Muhammad, Arif; Hossain, Shakhawat; Ilnytskyy, Yaroslav; Ghose, Abhijit; Kirkby, Charles; Ghasroddashti, Esmaeel; Kolb, Bryan; Kovalchuk, Olga (Frontiers MediaArts and ScienceDepartment of NeuroscienceDepartment of Biological SciencesUniversity of LethbridgeAlberta Epigenetics NetworkUniversity of CalgaryAlberta Health ServicesCanadian Institute for Advanced Research, 2016)
    Irradiated cells can signal damage and distress to both close and distant neighbors that have not been directly exposed to the radiation (naïve bystanders). While studies have shown that such bystander effects occur in the ...
  • Kolb, Bryan; Teskey, G. Campbell; Gibb, Robbin L. (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of Calgary, 2010)
    An important development in behavioral neuroscience in the past 20 years has been the demonstration that it is possible to stimulate functional recovery after cerebral injury in laboratory animals. Rodent models of ...
  • Milstein, Jean A.; Elnabawi, Ahmed; Vinish, Monika; Swanson, Thomas; Enos, Jennifer K.; Bailey, Aileen M.; Kolb, Bryan; Frost, Douglas O. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Maryland School of MedicineSt. Mary's College of MarylandUniversity of Lethbridge, 2013)
    Antipsychotic drugs are increasingly used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of early life antipsychotic drug treatment. Most ...

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