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Basic fibroblast growth factor in the injured brain

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author Rowntree, Sharon R.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-04-10T21:30:04Z
dc.date.available 2007-04-10T21:30:04Z
dc.date.issued 1995
dc.identifier.uri http://hdl.handle.net/10133/38
dc.description x, 123 p. ; 28 cm. en
dc.description.abstract Basic fibroblast growth factor (bFGF) has been implicated in the brain's trophic response to injury. This thesis examined the effects of endogenous bFGF on brain plasticity and recovery of behavioral function following cortical injury in adult rats. The first experiment investigated the post-lesion time course of the astrocytic expression of bFGF. Subsequent experiments examined the effects of injury-induced bFGF on neuroonal morphology, cortical morphology, and post-lesion behavioral deficits. Following motor cortex injury, endogenous bFGF prevented neuritic degeneration in layer V pyramidal neurons in Zilles' area Fr2 and promoted recovery of function in the Whishaw Reaching Task. Housing rats in an enriched environment prior to cortical injury enhanced the expression of bFGF but did not increase cortical thickness nor reduce post-lesion behavioral deficits (relative to laboratroy-housed rats). Collectively, these experiments indicate that injury-induced bFGF plays a role in potentiating recovery from brain damage. This implies that bFGF may be beneficial as a treatment following brain injury. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1995 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Fibroblast growth factors en
dc.subject Brain -- Wounds and injuries en
dc.subject Rats as laboratory animals en
dc.subject Physiology, Experimental en
dc.subject Dissertations, Academic en
dc.title Basic fibroblast growth factor in the injured brain en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Psychology

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