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Modeling middle cerebral artery stroke in rats : an examination of the skilled reaching impairments

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dc.contributor.advisor Whishaw, Ian Q. Gharbawie, Omar A. University of Lethbridge. Faculty of Arts and Science 2007-07-20T19:52:23Z 2007-07-20T19:52:23Z 2006
dc.description xiii, 345 leaves : ill. ; 29 cm. + 1 CD-ROM en
dc.description.abstract Middle cerebral artery (MCA) stroke can produce chronic incapacitating motor impairments. Understanding the neural basis of the motor syndromes is complicated by the diversity of neural structures damaged but the problem can be addressed in laboratory rats by inducing selective infarcts. Nevertheless, the motor syndromes that ensue from stroke in rats remain poorly understood and undermine its potential as a model for clinical stroke. The objective of the present thesis was to document the skilled reaching impairments from neocortical and subcortical MCA infarcts in rats. In addition, the integrity of the motor system components spared by the infarct was assessed neurophysiologically and neuroanatomically. Characteristic reaching impairments emerged from each infarct but there were also some overlapping features that might be explained by neural dysfunction extending beyond the boundaries of the infarct. The present studies showed that the laboratory rat is an ideal animal model for studying stroke, which should be of interest to both clinical and research scientists studying stroke. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2006 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Cerebrovascular disease -- Animal models en
dc.subject Cerebrovascular disease -- Research en
dc.subject Cerebrovascular disease -- Treatment en
dc.subject Motor ability -- Research en
dc.subject Rats as laboratory animals en
dc.title Modeling middle cerebral artery stroke in rats : an examination of the skilled reaching impairments en
dc.type Thesis en
dc.publisher.faculty Arts and Science en
dc.publisher.department Department of Neuroscience en Doctor of Philosophy Neuroscience
dc.organization University of Lethbridge
dc.librarysymbol ALU Arts and Science Sciences

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