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The effects of triclosan, 2,4-D, and their by-products on the adrenocortical cells of rainbow trout

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dc.contributor.advisor Hontela, Alice
dc.contributor.author Dann, Andrea B
dc.date.accessioned 2012-10-05T20:12:12Z
dc.date.available 2012-10-05T20:12:12Z
dc.date.issued 2011
dc.identifier.uri http://hdl.handle.net/10133/3154
dc.description ix, 139 leaves : ill. ; 29 cm en_US
dc.description.abstract The ubiquitous presence of anthropogenic chemicals and their transformation products in surface water represents a toxicological concern from both an ecological standpoint and a human perspective as many of these chemicals are capable of altering hormonal function. Endocrine disrupting compounds can be traced back to numerous sources and may fall under the class of pesticide, industrial chemical, pharmaceutical, personal care product, and/or heavy metals. The adrenal gland is the most common target for endocrine disruptors, although in comparison to the sex steroids, this system has received much less attention in published research. Corticosteroids play a pivotal role in many physiological processes, including immunity, cognitive function, growth, metabolism, reproduction, mineral balance, and blood pressure. A primary cell culture of rainbow trout adrenocortical cells was used to investigate the endocrine disrupting activity of two commonly detected water-borne toxicants, a personal care product, triclosan (TCS), a pesticide, dichlorophenoxyacetic acid (2,4-D), and their transformation products, methyl-triclosan (M-TCS) and dichlorophenol (DCP). Previously, it has been shown that TCS, 2,4-D, and DCP exhibit a potential for endocrine disruption, although it is currently unknown if these chemicals are capable of affecting corticosteroid balance. In this study, all four chemicals showed significant inhibitory effects on corticosteroid synthesis, even though there were considerable differences in their activity. The chemical that exhibited the highest toxicity was 2,4-D, followed by TCS, DCP, and M-TCS. Both parent-compounds proved to be more toxic than their degradation products. More research with suitable test systems is needed to determine the mechanism(s) of action of these corticosteroid disruptors and the health risk that they may present. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2011 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Rainbow trout -- Effect of pesticides on -- Research en_US
dc.subject Rainbow trout -- Effect of chemicals on -- Research en_US
dc.subject Rainbow trout -- Effect of water pollution on -- Research en_US
dc.subject Endocrine disrupting chemicals in water -- Research en_US
dc.subject Adrenocortical hormones -- Effect of pesticides on -- Research en_US
dc.subject Adrenocortical hormones -- Effect of chemicals on -- Research en_US
dc.subject Adrenocortical hormones -- Effect of water pollution on -- Research en_US
dc.subject Dichlorophenoxyacetic acid -- Toxicology en_US
dc.subject Hygiene products -- Toxicology en_US
dc.subject Dissertations, Academic en_US
dc.title The effects of triclosan, 2,4-D, and their by-products on the adrenocortical cells of rainbow trout en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US

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