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Characterization of Mannheimia haemolytica-specific bacteriophages

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dc.contributor.advisor Selinger, Brent
dc.contributor.advisor McAllister, Tim
dc.contributor.author Hsu, Yu-Hung
dc.date.accessioned 2012-10-04T22:04:23Z
dc.date.available 2012-10-04T22:04:23Z
dc.date.issued 2011
dc.identifier.uri http://hdl.handle.net/10133/3150
dc.description viii, 107 leaves : ill. ; 29 cm en_US
dc.description.abstract Mannheimia haemolytica is the principal bacterial agent associated with bovine respiratory disease (BRD). It has a significant economic impact on the beef feedlot industry. The current methods for BRD prevention and treatment have various problems and limitations, especially with reports of increased antimicrobial resistance in M. haemolytica. Bacteriophage therapy presents a novel method to mitigate M. haemolytica. This study aimed to isolate strictly lytic M. haemolytica-specific bacteriophages from bovine nasopharyngeal swabs and feedlot trough water. This was accompanied by an extensive characterization of temperate bacteriophages induced from representative strains of a M. haemolytica collection. Phage morphology, host specificity, genomic diversity, and comparative genomics were determined. Even though temperate bacteriophages are not ideal candidates for phage therapy, they can be engineered or modified to serve this function. Genome sequences of selected temperate bacteriophages also provide a foundation for future studies on the biology of these microorganisms. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2011 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Bacteriophages -- Genetics en_US
dc.subject Bacteriophages -- Research en_US
dc.subject Bacteriophages -- Therapeutic use en_US
dc.subject Bovine pneumonic pasteurellosis -- Treatment -- Research en_US
dc.subject Bovine pneumonic pasteurellosis -- Prevention -- Research en_US
dc.subject Communicable diseases in animals -- Treatment -- Research en_US
dc.subject Dissertations, Academic en_US
dc.title Characterization of Mannheimia haemolytica-specific bacteriophages en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US

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