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dc.contributor.supervisor Kolb, Bryan Richards, Sonja 2012-09-27T21:49:06Z 2012-09-27T21:49:06Z 2011
dc.description xi, 98 leaves; 29 cm en_US
dc.description.abstract This thesis examines both behavioral and anatomical effects of prenatal exposure of Valproic Acid (VPA) on Long Evans rats. Tactile stimulation (TS) is then used to investigate its’ effect on remediating any abnormalities VPA may produce. Several behavioral tests were done to assess the behavioral effects of VPA and TS. It was found that VPA had an effect of many of the tasks, whereas, TS had almost none with the exception of an effect on females in the elevated plus maze. However, anatomical data showed that TS had a profound effect on neuronal branch order, cell complexity, and spine density in pyramidal neurons in the medial prefrontal cortex, the orbitofrontal cortex and the amygdala. Where VPA decreased the above in all of these areas, TS increased neuronal complexity in the aforementioned structures. This study demonstrates that prenatal exposure to VPA is a viable model of autism in rats and that TS has significant anatomical effects in these animals as well as in control animals en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2011 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Autism -- Research en_US
dc.subject Valproic acid -- Physiological aspects en_US
dc.subject Rats as laboratory animals en_US
dc.subject Dissertations, Academic en_US
dc.title An animal model of autism : remediation with tactile stimulation en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US

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