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Browsing Projects & Theses by Author "Kovalchuk, Olga"

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Browsing Projects & Theses by Author "Kovalchuk, Olga"

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  • Zemp, Franz Joseph; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008Arts and ScienceDepartment of Biological Sciences, 2008)
    Bystander effects are traditionally known as a phenomenon whereby unexposed cells exhibit the molecular symptoms of stress exposure when adjacent or nearby cells are traversed by ionizing radiation. However, the realm of ...
  • Lowings, Michael D; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010Arts and ScienceDepartment of Biological Sciences, 2010)
    Stroke is one of the most common, and damaging, neurological afflictions. Stroke causes widespread and variable chronic effects, due to the limited regenerative ability of the adult brain. Altered gene expression ...
  • Koturbash, Igor; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008Arts and ScienceDepartment of Biological Sciences, 2008)
    Ionizing radiation (IR), along with being an important diagnostic and treatment modality, is a potent tumor-causing agent, and the risk of secondary radiation treatment-related cancers is a growing clinical problem. Now ...
  • Ilnytskyy, Yaroslav; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biomolecular Sciences, [c2010]Arts and ScienceDepartment of Biological Sciences, 2010)
    The classical paradigm of radiation biology is based on the notion that ionizing particle has to traverse a nucleus of a living cell in order to damage genetic material either directly or via production of short living ...
  • Merrifield, Matthew; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Science, c2011Arts and ScienceDepartment of Biological Sciences, 2011)
    PiRNAs and their Piwi family protein partners are part of a germline specific epigenetic regulatory mechanism essential for proper spermatogenesis, silencing of transposable elements, and maintaining germline genome ...
  • Tamminga, Jan; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008Arts and ScienceBiological Sciences, 2008)
    Approximately 45% of men will develop cancer during their lifetime; some of which will be of reproductive age (Canadian Cancer Society, 2008). Current advances in treatment regimens such as radiotherapy have significantly ...
  • McRae, Dorothy A; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010Arts and ScienceDepartment of Biological Sciences, 2010)
    Most breast cancer patients undergo radiation diagnostics and are also treated with radiotherapy. In addition to being an important treatment modality, ionizing radiation (IR) is a potent tumour-causing agent that has been ...
  • Luzhna, Lidiya; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2009Arts and ScienceDepartment of Biological Sciences, 2009)
    Breast cancer is a major cause of cancer-related death among women throughout the world. Treatment of breast cancer often fails due to the development of resistance to both chemo- and radiotherapy. The aim of this study ...
  • Filkowski, Jody; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, 2010Arts and ScienceDepartment of Biological Sciences, 2010)
    Cytotoxic chemotherapy is extremely important in adjuvant treatment of breast cancer. Yet, tumours frequently acquire chemoresistance that correlates with increased aggressiveness and poor prognosis. Three theories exist ...
  • Baker, Mike; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008Arts and ScienceDepartment of Biological Sciences, 2008)
    For over 100 years, cancer radiation therapy has provided patients with increased survival rates. Despite this success, radiation exposure poses a threat to the progeny of exposed parents. It causes transgenerational ...
  • Kutanzi, Kristy; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010Arts and ScienceDepartment of Biological Sciences, 2010)
    Epigenetics plays an important role in carcinogenesis with heritable changes in DNA methylation and histone modifications intricately linked to the initiation, promotion, and progression of cancer. Evidence shows that a ...

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