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Novel treatments for inducing cortical plasticity and functional restitution following motor cortex stroke

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dc.contributor.advisor Gibb, Robbin
dc.contributor.author Silasi, Gergely
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-05-23T17:39:12Z
dc.date.available 2007-05-23T17:39:12Z
dc.date.issued 2005
dc.identifier.uri http://hdl.handle.net/10133/278
dc.description ix, 149 leaves : ill. ; 29 cm. en
dc.description.abstract Stroke remains a leading cause of disability in the western world, with symptoms ranging in severity from mild congnitive or motor impairments, to severe impairments in both cognitive and motor domains. Despite ongoing research aimed at helping stroke patients the disease cannot be prevented or cured, therefore a large body of research has been aimed at identifying effective rehabilitative strategies. Based on our understanding of normal brain function, and the meachanisms mediating the limited spontaneous recovery that is observed following injury, factors that promote brain plasticity are likely to be effective treatments for stroke symptoms. The current thesis investigated three novel treatments (COX-2 inhibitor drug, vitamin supplement diet, and social experience) in a rat model of focal ischemia in the motor cortex. All three treatments have been previously shown to alter plasticity in the normal brain, however the current experiments show that the treatments have differential effects following stroke. The COX-2 inhibitors provided limited improvement in functional performance, whereas the vitamin supplement treatment had no effect. Social experience on the other hand was found to block the usually observed spontaneous improvements following the stroke. These results suggest that factors that alter dendritic plasticity may in fact serve as effective stroke treatments depending on the site and the mechanisms whereby the plastic changes are induced. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Cerebrovascular disease -- Animal models en
dc.subject Cerebrovascular disease -- Research en
dc.subject Cerebrovascular disease -- Treatment en
dc.subject Motor ability -- Research en
dc.subject Rats as laboratory animals en
dc.title Novel treatments for inducing cortical plasticity and functional restitution following motor cortex stroke en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience

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