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The role of the hippocampus and post-learning hippocampal activity in long-term consolidation of context memory

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dc.contributor.advisor Sutherland, Robert J
dc.contributor.author Gulbrandsen-MacDonald, Tine L
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2012-04-11T17:39:21Z
dc.date.available 2012-04-11T17:39:21Z
dc.date.issued 2011
dc.identifier.uri http://hdl.handle.net/10133/2635
dc.description x, 85 leaves : ill. ; 29 cm en_US
dc.description.abstract Sutherland, Sparks and Lehmann (2010) proposed a new theory of memory consolidation, termed Distributed Reinstatement Theory (DRT), where the hippocampus (HPC) is needed for initial encoding but some types of memories are established in non-HPC systems through post-learning HPC activity. An evaluation of the current methodology of temporary inactivation was conducted experimentally. By permanently implanting two bilateral guide cannulae in the HPC and infusing ropivacaine cellular activity could be reduced by 97%. Rats were trained in a context-fear paradigm. Six learning episodes distributed across three days made the memory resistant to HPC inactivation while three episodes did not. Blocking post-learning HPC activity following three of six training sessions failed to reduce the rat’s memory of the fearful context. These results fail to support DRT and indicate that one or more memory systems outside the HPC can acquire context memory without HPC post-event activity. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2011 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Hippocampus (Brain) -- Physiology en_US
dc.subject Hippocampus (Brain) -- Research en_US
dc.subject Memory -- Research en_US
dc.subject Memory -- Physiological aspects en_US
dc.subject Memory disorders en_US
dc.subject Brain -- Localization of functions en_US
dc.subject Rats as laboratory animals en_US
dc.subject Dissertations, Academic en_US
dc.title The role of the hippocampus and post-learning hippocampal activity in long-term consolidation of context memory en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US


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