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Non-targeted effects of ionizing radiation in vivo : epigenetic aspects / Yaroslav Ilinytskyy

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dc.contributor.advisor Kovalchuk, Olga Ilnytskyy, Yaroslav University of Lethbridge. Faculty of Arts and Science 2012-03-28T18:41:38Z 2012-03-28T18:41:38Z 2010
dc.description xi, 190 leaves ; 28 cm en_US
dc.description.abstract The classical paradigm of radiation biology is based on the notion that ionizing particle has to traverse a nucleus of a living cell in order to damage genetic material either directly or via production of short living free radicals. After DNA damage is introduced it can be either safely repaired and the cell can continue divisions unaltered; or it can result in a failure to repair and cells death; or finally, upon misrepair, the cell would be carrying genetic alteration that could result in cancer or developmental abnormality. Therefore modern risk estimations are based on the notion that nucleus is the true target of radiation effects and those are essentially stochastic with linear dependence on the dose. During the last two decades or so, a different idea was developed based on the observation that irradiated cells can communicate radiation induced stress signals to their unaffected neighbors and themselves become reprogrammed to maintained abnormal radiation-induced phenotype across multiple cellular divisions. Even more astonishingly this phenotype maybe transmitted by irradiated germ cells to unexposed progeny. Here we suggest that these non-targeted effects are maintained by epigenetic mechanisms and examine epigenetic underpinnings of bystander and transgenerational effects in vivo. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biomolecular Sciences, [c2010] en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Radiobiology en_US
dc.subject Radiation -- Physiological effect en_US
dc.subject Dissertations, Academic en_US
dc.title Non-targeted effects of ionizing radiation in vivo : epigenetic aspects / Yaroslav Ilinytskyy en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US Doctor of Philosophy PhD Biological Sciences
dc.organization University of Lethbridge
dc.librarysymbol ALU Arts and Science Sciences

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