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Metaplasticity : how experience during brain development influences the subsequent exposure to a drug of abuse

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author Muhammad, Arif
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2012-03-16T19:09:41Z
dc.date.available 2012-03-16T19:09:41Z
dc.date.issued 2011
dc.identifier.uri http://hdl.handle.net/10133/2623
dc.description xii, 263 leaves : ill. ; 29 cm en_US
dc.description.abstract The influence of experience during brain development was investigated on juvenile behavior, adult amphetamine sensitization, and neuronal structural plasticity in rats. Two experiential factors (i.e., tactile stimulation and stress) were studied either before or soon after birth. Early experience feminized social behavior in males; however, only stress enhanced anxiety-like behavior in males. Repeated amphetamine administration resulted in the development and persistence of behavioral sensitization. However, tactile stimulation attenuated the drug-induced behavioral sensitization whereas stress failed to influence the degree of sensitization. Neuroanatomical findings revealed that early experience altered the cortical and subcortical structures. Furthermore, drug exposure reorganized the brain structures involved in addiction but early experience prevented the drug-associated changes. Early adverse experience influences the subsequent exposure to a drug of abuse at anatomical level whereas a favorable experience has an effect both at behavioral and anatomical levels and thus may play a protective role against drug-induced sensitization and addiction. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2011 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Brain -- Effect of drugs on -- Research en_US
dc.subject Brain -- Effect of stress on -- Research en_US
dc.subject Brain -- Adaptation en_US
dc.subject Prefrontal cortex -- Effect of drugs on -- Research en_US
dc.subject Prefrontal cortex -- Effect of stress on -- Research en_US
dc.subject Prefrontal cortex -- Adaptation en_US
dc.subject Nucleus accumbens -- Effect of drugs on -- Research en_US
dc.subject Nucleus accumbens -- Effect of stress on -- Research en_US
dc.subject Nucleus accumbens -- Adaptation en_US
dc.subject Developmental neurophysiology en_US
dc.subject Neuroplasticity en_US
dc.subject Rats as laboratory animals en_US
dc.subject Dissertations, Academic en_US
dc.title Metaplasticity : how experience during brain development influences the subsequent exposure to a drug of abuse en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Doctor of Philosophy
dc.degree.discipline Neuroscience
dc.organization University of Lethbridge
dc.librarysymbol ALU
dc.degree.field Arts and Science
dc.degree.subfield Sciences

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