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Species differences in selenium toxicity : linking cellular responses to population effects

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dc.contributor.advisor Hontela, Alice
dc.contributor.author Miller, Lana L
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2012-03-09T21:40:27Z
dc.date.available 2012-03-09T21:40:27Z
dc.date.issued 2011
dc.identifier.uri http://hdl.handle.net/10133/2622
dc.description xiv, 171 leaves : ill., maps ; 29 cm en_US
dc.description.abstract Model organisms are often used in ecotoxicological studies and environmental risk assessments; however, species differences in responses to toxicants exist. A meta-analysis identified normal biomarker ranges for rainbow trout (RT) and brook trout (BT), and showed that RT had greater whole-body lipids and plasma T4 levels than BT. Exposure to selenium inhibited cortisol secretion of trout adrenocortical cells; however, RT were more sensitive than BT. To investigate species vulnerability at the individual level, RT and BT were stocked into reference and selenium-contaminated pit lakes. Fish accumulated more Se from selenium-contaminated than reference lakes, and selenium accumulation was similar between species. Chronic selenium exposure had a greater energetic cost for RT than BT, but this was mitigated by food availability. Chronic selenium exposure decreased plasma T3 and T4 levels, but did not alter other endocrine or oxidative stress biomarkers. This project highlights the need for both species- and site-specific risk assessments. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2011 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Brook trout -- Effect of selenium on -- Research en_US
dc.subject Rainbow trout -- Effect of selenium on -- Research en_US
dc.subject Environmental toxicology -- Research en_US
dc.subject Biochemical markers en_US
dc.subject Dissertations, Academic en_US
dc.title Species differences in selenium toxicity : linking cellular responses to population effects en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.degree.level Doctor of Philosophy
dc.degree.discipline Biological Sciences
dc.organization University of Lethbridge
dc.librarysymbol ALU
dc.degree.field Arts and Science
dc.degree.subfield Sciences

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