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Radiation induced epigenetic dysregulation in rat mammary gland tissue / Dorothy A. McRae

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dc.contributor.advisor Kovalchuk, Olga
dc.contributor.author McRae, Dorothy A
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2012-02-24T19:11:14Z
dc.date.available 2012-02-24T19:11:14Z
dc.date.issued 2010
dc.identifier.uri http://hdl.handle.net/10133/2615
dc.description xi, 120 leaves ; 29 cm en_US
dc.description.abstract Most breast cancer patients undergo radiation diagnostics and are also treated with radiotherapy. In addition to being an important treatment modality, ionizing radiation (IR) is a potent tumour-causing agent that has been linked to breast cancer development. However, the exact molecular etiology of IR-induced mammary gland carcinogenesis remains unknown. We set out to analyze the role of DNA methylation in mammary gland responses to low dose IR using a well-established rat model. We also studied low dose IR effects on global gene expression and microRNAome. We found that exposure to low, mammography-like dose of IR led to a significant loss of global DNA methylation in rat mammary gland tissue. Furthermore, low dose IR significantly affected rat mammary gland transcriptome and microRNAome. The datasets generated within the scope of this thesis may be used to identify novel predictive biomarkers for assessment of the magnitude of IR effects on mammary gland tissue. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Ionizing radiation -- Health aspects en_US
dc.subject Ionizing radiation -- Physiological effect en_US
dc.subject Ionizing radiation -- Dose-response relationship en_US
dc.subject DNA -- Methylation en_US
dc.subject Breast -- Cancer -- Radiotherapy en_US
dc.subject Dissertations, Academic en_US
dc.title Radiation induced epigenetic dysregulation in rat mammary gland tissue / Dorothy A. McRae en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US

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