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The molecular mechanisms underlying epigenetics of the stress response in the cerebellum in a rat model

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dc.contributor.advisor Kovalchuk, Igor
dc.contributor.advisor Metz, Gerlinde
dc.contributor.author Babenko, Olena Mykolayivna
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2012-02-09T23:32:57Z
dc.date.available 2012-02-09T23:32:57Z
dc.date.issued 2010
dc.identifier.uri http://hdl.handle.net/10133/2604
dc.description xii, 109 leaves. : ill. ; 29 cm en_US
dc.description.abstract Previous findings showed that mild chronic restraint stress causes motor impairments in rats. These behavioural impairments might be related to molecular changes in brain areas that regulate motor functions, such as the cerebellum. Little is known about the role of the cerebellum in stress-induced behavioural alteration. We hypothesized that alteration in animal behaviour after chronic restraint stress is due to brain-specific changes in miRNA and proteins encoding gene expression. Our results revealed that expression of three miRNAs and 39 mRNAs was changed significantly after two weeks of stress. Furthermore, we verified one putative target for one of the changed miRNAs and expression of four randomly selected genes. Changes in gene expression disappeared after two weeks of recovery from stress. These findings provide a novel insight into stress-related mechanisms of gene expression underlying altered behavioural performance. The observations bear implications for the prevention and treatment of stress-related disorders and disease. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Stress (Physiology) -- Research en_US
dc.subject Cerebellum -- Effect of stress on -- Research en_US
dc.subject Rats as laboratory animals en_US
dc.subject Rats -- Effect of stress on en_US
dc.subject Epigenetics -- Research en_US
dc.subject Dissertations, Academic en_US
dc.title The molecular mechanisms underlying epigenetics of the stress response in the cerebellum in a rat model en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US

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