dc.contributor.supervisor |
Sutherland, Robert J. |
|
dc.contributor.author |
Spanswick, Simon |
|
dc.contributor.author |
University of Lethbridge. Faculty of Arts and Science |
|
dc.date.accessioned |
2011-12-22T22:28:09Z |
|
dc.date.available |
2011-12-22T22:28:09Z |
|
dc.date.issued |
2010 |
|
dc.identifier.uri |
http://hdl.handle.net/10133/2587 |
|
dc.description |
xii, 191 leaves : ill. (chiefly col.) ; 28 cm |
en_US |
dc.description.abstract |
Long-term adrenalectomy (ADX) results in a specific loss of dentate gyrus granule cells in the hippocampus of adult rats, occurring over a period of weeks to months. This loss of granule cells results in cognitive deficits in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deficits in cognition are similar to those experienced by patient populations suffering from a variety of pathological conditions. Here we present an animal model by which we use ADX to produce a loss of granule cells within the hippocampus of rats. We also provide experimental evidence for a treatment strategy by which the lost granule cells may be replaced, with the goal of functional recovery in mind. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.publisher |
Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2010 |
en_US |
dc.relation.ispartofseries |
Thesis (University of Lethbridge. Faculty of Arts and Science) |
en_US |
dc.subject |
Dentate gyrus -- Research |
en_US |
dc.subject |
Hippocampus (Brain) -- Research |
en_US |
dc.subject |
Adrenalectomy |
en_US |
dc.subject |
Developmental neurobiology |
en_US |
dc.subject |
Brain -- Research |
en_US |
dc.subject |
Rats as laboratory animals |
en_US |
dc.subject |
Neuroplasticity -- Research |
en_US |
dc.subject |
Dissertations, Academic |
en_US |
dc.title |
Adrenalectomy-induced neuronal degeneration : development of a novel animal model of cognitive dysfuntion and neurogenic treatment strategies |
en_US |
dc.type |
Thesis |
en_US |
dc.publisher.faculty |
Arts and Science |
en_US |
dc.publisher.department |
Department of Neuroscience |
en_US |
dc.degree.level |
Doctor of Philosophy |
|
dc.degree.level |
PhD |
|
dc.degree.discipline |
Neuroscience |
|
dc.organization |
University of Lethbridge |
|
dc.librarysymbol |
ALU |
|
dc.degree.field |
Arts and Sciences |
|