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Adrenalectomy-induced neuronal degeneration : development of a novel animal model of cognitive dysfuntion and neurogenic treatment strategies

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dc.contributor.advisor Sutherland, Robert
dc.contributor.author Spanswick, Simon
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2011-12-22T22:28:09Z
dc.date.available 2011-12-22T22:28:09Z
dc.date.issued 2010
dc.identifier.uri http://hdl.handle.net/10133/2587
dc.description xii, 191 leaves : ill. (chiefly col.) ; 28 cm en_US
dc.description.abstract Long-term adrenalectomy (ADX) results in a specific loss of dentate gyrus granule cells in the hippocampus of adult rats, occurring over a period of weeks to months. This loss of granule cells results in cognitive deficits in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deficits in cognition are similar to those experienced by patient populations suffering from a variety of pathological conditions. Here we present an animal model by which we use ADX to produce a loss of granule cells within the hippocampus of rats. We also provide experimental evidence for a treatment strategy by which the lost granule cells may be replaced, with the goal of functional recovery in mind. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2010 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Dentate gyrus -- Research en_US
dc.subject Hippocampus (Brain) -- Research en_US
dc.subject Adrenalectomy en_US
dc.subject Developmental neurobiology en_US
dc.subject Brain -- Research en_US
dc.subject Rats as laboratory animals en_US
dc.subject Neuroplasticity -- Research en_US
dc.subject Dissertations, Academic en_US
dc.title Adrenalectomy-induced neuronal degeneration : development of a novel animal model of cognitive dysfuntion and neurogenic treatment strategies en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Doctor of Philosophy
dc.degree.discipline Neuroscience
dc.organization University of Lethbridge
dc.librarysymbol ALU
dc.degree.field Arts and Sciences

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