Institutional Repository

Mathematical modeling of eukaryotic gene expression

DSpace/Manakin Repository

Show simple item record

dc.contributor.advisor Roussel, Marc R
dc.contributor.author Tang, Terry
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2011-12-07T21:39:47Z
dc.date.available 2011-12-07T21:39:47Z
dc.date.issued 2010
dc.identifier.uri http://hdl.handle.net/10133/2567
dc.description xi, 102 leaves ; 28 cm en_US
dc.description.abstract Using the Gillespie algorithm, the export of the mRNA molecules from their transcription site to the nuclear pore complex is simulated. The effect of various structures in the nu- cleus on the efficiency of export is discussed. The results show that having some of the space filled by chromatin near the mRNA synthesis site shortens the transport time. Next, the complete eukaryotic gene expression including transcription, splicing, mRNA export, translation, and mRNA degradation is modeled using delay stochastic simulation. This allows for the study of stochastic effects during the process and on the protein production rate patterns. Various protein production patterns can be produced by adjusting the poly-A tail length of the mRNA and the promoter efficiency of the gene. After that, the opposing effects of the chromatin density on the seeking time of the transcription factors for the promoter and the exit time of the mRNA product are discussed. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry, 2010 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Messenger RNA -- Research en_US
dc.subject Proteins -- Synthesis en_US
dc.subject Eukaryotic cells -- Research en_US
dc.subject Gene expression en_US
dc.subject Chromatin en_US
dc.subject Cytology -- Mathematical models en_US
dc.subject Dissertations, Academic en_US
dc.title Mathematical modeling of eukaryotic gene expression en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Chemistry and Biochemistry en_US
dc.degree.level Doctor of Philosophy
dc.degree.discipline Chemistry & Biochemistry
dc.organization University of Lethbridge
dc.librarysymbol ALU
dc.degree.field Arts and Sciences
dc.degree.subfield Sciences

Files in this item

This item appears in the following Collection(s)

Show simple item record

Related Items

Search DSpace


Advanced Search

Browse

My Account

Statistics