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dc.contributor.supervisor Kovalchuk, Igor Filkowski, Jody University of Lethbridge. Faculty of Arts and Science 2007-05-17T14:48:37Z 2007-05-17T14:48:37Z 2004
dc.description xiii, 119 leaves ; 29 cm. en
dc.description.abstract Resistance (R) genes, a key factor in determining the resistance of plants, have been shown often to be highly allelic entities existing in duplicated regions of the genome. This characteristic suggests that R-gene acquisition may have arisen through frequent genetic rearrangements as a result of transient, reduced genome stability. Tabacco plants transgenic for a recombination construct exhibited reduced genome stability upon infection with a virulent pathogen (tobacco mosaic virus). The reduced genome stability manifested as an increase in recombination events in the transgene. Such increases were observed following a virulent pathogen attack. This increase in recombination was shown to be systemic and was observed prior to systemic viral movement suggesting the presence of a systemic recombination signal. Further molecular analyses revealed that specific R-gene loci experience a large frequency of rearrangements following a virulent pathogen encounter. The possible targeting of instability to R-gene regions may be controlled through epigenetic processes, in particular, DNA methylation. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, 2004 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Plants -- Disease and pest resistance -- Genetic aspects en
dc.subject Plant diseases -- Genetic aspects en
dc.subject Plant molecular genetics en
dc.title The effect of pathogens on plant genome stability en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Biological Sciences Masters

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