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The effect of pathogens on plant genome stability

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dc.contributor.advisor Kovalchuk, Igor
dc.contributor.author Filkowski, Jody
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-05-17T14:48:37Z
dc.date.available 2007-05-17T14:48:37Z
dc.date.issued 2004
dc.identifier.uri http://hdl.handle.net/10133/254
dc.description xiii, 119 leaves ; 29 cm. en
dc.description.abstract Resistance (R) genes, a key factor in determining the resistance of plants, have been shown often to be highly allelic entities existing in duplicated regions of the genome. This characteristic suggests that R-gene acquisition may have arisen through frequent genetic rearrangements as a result of transient, reduced genome stability. Tabacco plants transgenic for a recombination construct exhibited reduced genome stability upon infection with a virulent pathogen (tobacco mosaic virus). The reduced genome stability manifested as an increase in recombination events in the transgene. Such increases were observed following a virulent pathogen attack. This increase in recombination was shown to be systemic and was observed prior to systemic viral movement suggesting the presence of a systemic recombination signal. Further molecular analyses revealed that specific R-gene loci experience a large frequency of rearrangements following a virulent pathogen encounter. The possible targeting of instability to R-gene regions may be controlled through epigenetic processes, in particular, DNA methylation. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, 2004 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Plants -- Disease and pest resistance -- Genetic aspects en
dc.subject Plant diseases -- Genetic aspects en
dc.subject Plant molecular genetics en
dc.title The effect of pathogens on plant genome stability en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Biological Sciences

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