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Experience dependent plasticity of stroke outcome

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dc.contributor.advisor Prusky, Glen
dc.contributor.author Rakai, Brooke D.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2011-08-19T19:22:04Z
dc.date.available 2011-08-19T19:22:04Z
dc.date.issued 2008
dc.identifier.uri http://hdl.handle.net/10133/2518
dc.description vi, 135 p. : ill. ; 29 cm en_US
dc.description.abstract Stroke outcome is highly variable. Experiments in this thesis test the hypothesis that experience prior to a stroke is an important variable in the manifestation of stroke. Optokinetic tracking was used to evaluate the effects of visual cortex stroke and MCA occlusion in rats. Normal laboratory rats showed a small, but significant decrease in tracking thresholds following visual cortex stroke. Animals with developmental visuomotor experience or reach training experience in adulthood, however, had tracking thresholds which were substantially increased, and the effects of visual cortex strokes were greater. MCA occlusions did not affect tracking behaviour. These data indicate that specific experiences engage neural plasticity that can alter brain function. These changes can, in turn, affect the behavioural manifestation of a stroke. Understanding the effect that environmental experience has on stroke outcome promises to enable better characterization of strokes, and set appropriate behavioural baselines for the measurement of recovery of function. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2008 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Cerebrovascular disease en_US
dc.subject Cerebrovascular disease -- Animal models en_US
dc.subject Cerebrovascular disease -- Research en_US
dc.subject Neuroplasticity en_US
dc.subject Neuroplasticity -- Research en_US
dc.subject Neuroplasticity -- Animal models en_US
dc.subject Rats as laboratory animals en_US
dc.subject Dissertations, Academic en_US
dc.title Experience dependent plasticity of stroke outcome en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US

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