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The role of epigenetics in the rat mammary gland

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dc.contributor.advisor Kovalchuk, Olga
dc.contributor.author Kutanzi, Kristy
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2011-08-08T20:27:14Z
dc.date.available 2011-08-08T20:27:14Z
dc.date.issued 2010
dc.identifier.uri http://hdl.handle.net/10133/2492
dc.description xiv, 190 leaves : ill. (chiefly col.) ; 29 cm en_US
dc.description.abstract Epigenetics plays an important role in carcinogenesis with heritable changes in DNA methylation and histone modifications intricately linked to the initiation, promotion, and progression of cancer. Evidence shows that a number of chemical and physical agents can induce epigenetic changes during carcinogenesis. Two such agents, estrogen and ionizing radiation, are generally recognized as being carcinogenic. Yet the epigenetic repercussions of these carcinogens remain relatively unknown. More importantly, the combined effect of these carcinogens has never been addressed in vivo from an epigenetic standpoint. Therefore, we focused on the effect of estrogen and ionizing radiation applied separately or in conjunction. We have found that the exposure to estrogen, either alone or in combination with radiation, induced pronounced morphological alterations, which was paralleled by modifications to the epigenomic landscape in the mammary gland. The results obtained from these rodent models can potentially be extrapolated to humans. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Carcinogenesis en_US
dc.subject Estrogen en_US
dc.subject Ionizing radiation en_US
dc.subject Rats as laboratory animals en_US
dc.subject Epigenesis en_US
dc.subject Mammary glands -- Cancer en_US
dc.subject Breast -- Cancer -- Research en_US
dc.subject Dissertations, Academic en_US
dc.title The role of epigenetics in the rat mammary gland en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.degree.level Doctor of Philosophy
dc.organization University of Lethbridge
dc.librarysymbol ALU
dc.degree.field Arts and Sciences

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