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Factors influencing functional recovery following hemidecortication in rats

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author Day, Morgan M.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-05-13T20:30:38Z
dc.date.available 2007-05-13T20:30:38Z
dc.date.issued 2005
dc.identifier.uri http://hdl.handle.net/10133/247
dc.description x, 123 leaves ; 29 cm. en
dc.description.abstract Large neocortical lesions, such as hemidecortication, are detrimental for motor and cognitive skills. This thesis investigates the effect of age at the time of lesion on functional outcome. Attempts were then made to improve the outcome by using two simple treatments, tactile stimulation and Fibroblast Growth Factor-2 (FGF-2). The functional outcome of animals was measured using a series of behavioural tests (Morris water task, skilled reaching, forelimb placing during spontaneous vertical exploration, and the sunflower seed task). A qualitative difference was noted between animals that received hemidecortication at post natal day ten (P 10) versus animals that received a hemidecortication in adulthood (postnatal day, P 90). When the tactile stimulation treatment was used on animals that received P 10 hemidecortication, cognitive and motor improvements were noted. The same was not true for injections of FGF-2. When given after P 10 hemidecortication, this treatment impaired the cognitive abilities of rats in the Morris water task. There are two main points from this project: 1) overall functional recovery is not better or worse but simply different based on the age at which the trauma occurred and 2) treatments have varied success with different types of brain injury. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Facutly or Arts and Science, 2005 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Brain -- Wounds and injuries -- Research en
dc.subject Rats as laboratory animals en
dc.subject Brain damage -- Research en
dc.subject Cerebral cortex -- Wounds and inuries -- Research en
dc.title Factors influencing functional recovery following hemidecortication in rats en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience

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