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A behavioural analysis of visual pattern separation ability by rats : effects of damage to the hippocampus

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dc.contributor.advisor Sutherland, Robert
dc.contributor.author Spanswick, Simon
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-05-13T20:29:37Z
dc.date.available 2007-05-13T20:29:37Z
dc.date.issued 2005
dc.identifier.uri http://hdl.handle.net/10133/236
dc.description ix, 84 leaves : ill. ; 29 cm. en
dc.description.abstract Different events usually contain similar elements that can contribute to interference during memory encoding and retrieval. The hippocampus (HPC), a structure that is critically involved in some forms of memory, has been hypothesized to reduce interference between memories with overlapping content, thus facilitating correct recall. Pattern separation is one hypothetical process whereby input ambiguity is reduced. Here we test the hypothesis that the HPC and/or dentate gyrus (DG) are important for pattern separation by measuring performance by rats with damage in tasks that require discrimination between visual stimuli that share systematically varying numbers of common elements. Rats with HPC damage were slower to resolve discriminations with minimal degrees of overlap. Lesions of the DG did not affect the ability of rats to deal with overlap, suggesting a dissociation between the HPC and DG. Our results provide partial support for the idea that the HPC contributes to the pattern separation process. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Memory -- Physiological aspects en
dc.subject Memory -- Research en
dc.subject Rats as laboratory animals en
dc.subject Hippocampus (Brain) -- Physiology en
dc.title A behavioural analysis of visual pattern separation ability by rats : effects of damage to the hippocampus en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience

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