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Dietary choline and vitamin/mineral supplement for recovery from early cortical injury

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author Halliwell, Celeste
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-05-12T20:35:08Z
dc.date.available 2007-05-12T20:35:08Z
dc.date.issued 2003
dc.identifier.uri http://hdl.handle.net/10133/222
dc.description xiv, 191 leaves : ill. ; 28 cm. en
dc.description.abstract Early cortical injury has been attributed to the consequential effects of various factors, such as alcohol, drug addiction, smoking, and inadequate nutrient intakes during periods of pregnancy and lactation, or delivery of infants by forceps, and premature deliveries. These are only a few examples of circumstances, or "injury", that may result in disorders ranging from mild learning difficulties to aggressive behaviour. Injury to the cortex during the early years of development has been know to result in poor behavioural outcome into adulthood. Presently, the most common form of treatment includes a pharmacological agent, which may be accompanied with behavioral modification therapies supported by families. As an alternative form of therapy towards the treatment of early cortical injury, choline and a vitamin and mineral supplement (EM Power+) were used to determine the possibilities of nutrition intervention in an animal model. The injuries were incurred by aspiration lesion at days three, (Exp.1) and four, (Exp.2) and lesions were localized to the midline medial frontal cortex in some rats, while a different group of rats received lesions in the posterior parietal cortex. The pre-and postnatal choline treated animals showed favorable results for the medial frontal lesions, and the postnatal vitamin supplement treated animals showed favorable results for treatment in both medial frontal and posterior parietal lesions. All animals were tested in adulthood indicating that nutrition intervention is very beneficial for alleviating some of the functional deficits commonly seen from early cortical injury. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Brain -- Wounds and injuries -- Diet therapy en
dc.subject Minerals in nutrition -- Therapeutic use en
dc.subject Choline -- Therapeutic use en
dc.subject Rats as laboratory animals en
dc.subject Brain damaged children -- Nutrition en
dc.subject Dissertations, Academic en
dc.subject Brain damage -- Research en
dc.title Dietary choline and vitamin/mineral supplement for recovery from early cortical injury en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience

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