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Reduced peri-infarct dysfunction with pre-stroke exercise : molecular and physiological correlates

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dc.contributor.advisor Kleim, Jeffrey
dc.contributor.author Cooper, Natalie R.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-05-12T20:34:28Z
dc.date.available 2007-05-12T20:34:28Z
dc.date.issued 2003
dc.identifier.uri http://hdl.handle.net/10133/215
dc.description 140 leaves : ill. (some col.) ; 29 cm. en
dc.description.abstract The effects of pre-stroke exercise and levesl of brain-derived neurotrophic factor (BDNF) on behavioural and functional recovery were examined following focal cortical ischemic infarct. Intracortical microstimulation (ICMS) was used to derive topographical maps of forelimb representations within the motor cortex and ischemia was induced via bipolar coagulation of surface vasculature. One month of excerise prior to ischemia significantly increased the amount of peri-infarct movement represnetations and initiates vascular changes within motor cortex. Further, this exercise-induced preservation of peri-infarct movement representations is associated with behavioural recovery and is dependent on BDNF levels in the motor cortex. These results provide further support for the idea that endurance exercise prior to stroke may enhance functional and behavioural recovery. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Cerebrovascular disease -- Research en
dc.subject Cerebrovascular disease -- Patients -- Rehabilitation en
dc.subject Exercise -- Health aspects en
dc.title Reduced peri-infarct dysfunction with pre-stroke exercise : molecular and physiological correlates en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience

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