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Basic fibroblast growth factor enhances recovery in rats

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author Waite, Wendy Lou
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-05-12T20:00:49Z
dc.date.available 2007-05-12T20:00:49Z
dc.date.issued 2003
dc.identifier.uri http://hdl.handle.net/10133/208
dc.description xvi, 223 leaves : ill. ; 29 cm. en
dc.description.abstract This thesis examined the role of exogenous basic fibroblast growth factor (FGF-2) in stimulating recovery after early cortical injury. Rats with medial prefrontal cortex (MFC), posterior parietal cortex (PPC), or sham lesions at postnatal day 3 (P3) received one of three variations of FGF-2 treatment: postnatal FGF-2 that was either pre-mixed or prepared daily, or prenatal FGF-2, and tested in adulthood. Behavioral tests used were: 1) the Morris Water task and, 2) the Whishaw Tray Reaching task. The level of functional recovery attained was dependent on FGF-2 preparation and the developmental period. MFC lesion rats showed good recovery but there was a differntial effect of pre and postnatal FGF-2 that appeared to be related to task. PPC rats showed greater recovery after postnatal rather than prenatal treatment. Anatomical changes were restricted to groups with relatively good functional recovery. These findings suggest a multifunctional role of FGF-2 in the injured brain. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Fibroblast growth factors -- Research en
dc.subject Rats as laboratory animals en
dc.subject Brain -- Wounds and injuries -- Research en
dc.subject Physiology, Experimental en
dc.subject Dissertations, Academic en
dc.title Basic fibroblast growth factor enhances recovery in rats en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience

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