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dc.contributor.supervisor Kolb, Bryan Hastings, Erica University of Lethbridge. Faculty of Arts and Science 2007-05-01T14:19:28Z 2007-05-01T14:19:28Z 2003
dc.description xv, 177 leaves : ill. (some col.) ; 29 cm. en
dc.description.abstract This thesis focuses on the effects of pharmacological and environmental interventions following perinatal prefrontal cortex lesions. Rats given postnatal day 3 medial prefrontal cortex lesions were provided with one of the following treatments: basic fibroblast growth factor (bFGF), complex-housing, tactile stimulation, or a combined treatment of both bFGF and tactile stimulation or bFGF and complex-housing. Rats given postnatal day 3 orbital prefrontal cortex lesions were housed in a complex environment. The findings of these studies suggest that bFGF, complex-housing or tactile stimulation are beneficial after early brain injury. The combined treatment of bFGF with complex-housing provides a synergistic effect, as the combined condition is more advantageous than bFGF alone. In contrast, the combined treatment of bFGF with tactile stimulation produced adverse effects. These results suggest that pharmacological and environmental manipulations change cortical plasticity and therefore functional recovery after neonatal cortical injury. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Brain research en
dc.subject Brain -- Wounds and injuries en
dc.subject Brain -- Wounds and injuries -- Treatment en
dc.subject Rats as laboratory animals en
dc.title Environmental and pharmacological intervention following cortical brain injury en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience Masters

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