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The role of cholinergic and serotonergic neocortical projections in controlling skilled movement in rats : evaluation of a model of dementia

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dc.contributor.advisor Whishaw, Ian
dc.contributor.author Gharbawie, Omar A.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-04-30T21:18:33Z
dc.date.available 2007-04-30T21:18:33Z
dc.date.issued 2002
dc.identifier.uri http://hdl.handle.net/10133/177
dc.description vii, 166 leaves : ill. ; 28 cm. en
dc.description.abstract The ascending cholinergic and serotonergic projections are central to cortical activation and normal behavior. The objective of this thesis was to determine whether unilaterally damaging both of these systems would disrupt the production of skilled movements on the contralateral side of the body. Rats received unilateral damage to either the ascending cholinergic, or serotonergic, or both projections. The respective lesions reduced neocortical leveles of acetylcholine and serotonin as assessed by acetylcholinesterase reactivity and immunohistochemical staining for serotonin. Subjects were assessed on a battery of sensorimotor tasks sensitive to neocortical integrity. The cholinergic lesion produced mild deficits on some taks but damage to both together did not abolish skilled movement. The impairments are decreased in relation to the severe effects of bilateral lesions. The results show that the sensorimotor cortex remains functional following deafferentation of both cholinergic and serotonergic afferents. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2002 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dementia -- Research en
dc.subject Rats -- Behavior en
dc.subject Cholinergic mechanisms -- Research en
dc.subject Serotoninergic mechanisms -- Research en
dc.subject Dissertations, Academic en
dc.title The role of cholinergic and serotonergic neocortical projections in controlling skilled movement in rats : evaluation of a model of dementia en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience

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