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Basic fibroblast growth factor improves physiological, anatomical, and functional outcome from bilateral lesions to motor cortex at postnatal day 10 in the rat

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author Monfils, Marie-H.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-03-26T14:33:22Z
dc.date.available 2007-03-26T14:33:22Z
dc.date.issued 2005
dc.identifier.uri http://hdl.handle.net/10133/16
dc.description xiii, 171 p. : ill. ; 28 cm. en
dc.description.abstract Basic fibroblast growth factor (FGF-2) is a trophic molecule involved in a number of functions within the central nervous system (CNS), including a prominent role in the regulation of CNS responses to injury. Prior studies suggest that rats recover differently from injury inflicted to different regions and at different ages throughout development, and that FGF-2 might underlie this phenomenon. This thesis examined whether the functional and structural outcome following bilateral injury to the motor cortex inflicted at postnatal day (P10) could be ameliorated by exogenous administration of a growth factor (FGF-2). Four complimentary studies were conducted that each assessed the role of FGF-2 in mediating recovery from bilateral motor cortex injury inflicted at P10. We found that FGF-2 improves physiological, anatomical, and functional outcome from bilateral lesions to motor cortex at P10. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Department of Psychology and Neuroscience, 2005 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Fibroblast growth factors en
dc.subject Brain -- Wounds and injuries en
dc.subject Rats as laboratory animals en
dc.subject Physiology, Experimental en
dc.subject Dissertations, Academic en
dc.title Basic fibroblast growth factor improves physiological, anatomical, and functional outcome from bilateral lesions to motor cortex at postnatal day 10 in the rat en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience
dc.degree.level Doctor of Philosophy
dc.degree.discipline Neuroscience
dc.organization University of Lethbridge
dc.librarysymbol ALU
dc.degree.field Arts and Science
dc.degree.subfield Sciences

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