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An analysis of poststroke motor dysfunction and cerebral reorganization in rats

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author Gonzalez, Claudia L. R.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-03-23T20:55:32Z
dc.date.available 2007-03-23T20:55:32Z
dc.date.issued 2004
dc.identifier.uri http://hdl.handle.net/10133/15
dc.description xviii, 299 leaves : ill. (some col.) ; 29 cm. en
dc.description.abstract This thesis investigates the behavioural and anatomical correlates of recovery from motor cortex damage in rats. The effectiveness of behavioural, pharmacological, and regenerative treatments was investigated using models of focal stroke. Chronic bilateral motor deficits were found after motor cortex damage induced by various methods. These behavioural deficits were similar in severity and duration although they were correlated with different patterns of reorganization seen in Golgi-stained tissue. Animals with motor cortex injury benefited from postinjury olfactory stimulation, chronic administration of nicotine, and infusions of epidermal growth factor followed by erythroprotein. Different mechanisms of plasticity in remaining cortical circuits are discussed as possible candidates responsible for the behavioural improvement. The current thesis expands the current knowledge of the effects of adult cortical damage to ares critical to motor control. It may also stimulate research on therapies and possible mechanisms that might enhance recovery after stroke. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2004 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Cerebrovascular disease -- Animal models en
dc.subject Cerebrovascular disease -- Research en
dc.subject Motor ability -- Research en
dc.subject Rats as laboratory animals en
dc.title An analysis of poststroke motor dysfunction and cerebral reorganization in rats en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience
dc.degree.level Doctor of Philosophy
dc.degree.discipline Psychology and Neuroscience
dc.organization University of Lethbridge
dc.librarysymbol ALU
dc.degree.field Arts and Science
dc.degree.subfield Science

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