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A mouse model for studying stroke induced impairments, recovery, and compensation in the motor cortex

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dc.contributor.advisor Whishaw, Ian
dc.contributor.author Farr, Tracy Deanne
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-04-25T19:38:05Z
dc.date.available 2007-04-25T19:38:05Z
dc.date.issued 2003
dc.identifier.uri http://hdl.handle.net/10133/156
dc.description viii, 115 leaves : ill. ; 29 cm. en
dc.description.abstract Stroke is the third leading cause of death and survivors suffer motor impairments. The rodent sensorimotor system is similar to the human's, making rodents a good model to study the effects of stroke. Transgenic technology makes the mouse a desirable stroke model, however, there are few behavioural tests to assess behavioural outcome. This thesis evaluates mice subjected to permanent or temporary occlusion focal motor cortex strokes in a skilled reaching task. The first experiment documents changes in skilled movements in mice with a permanent occlusion focal motor cortex stroke. The second experiment is identical but uses a temporary occlusion focal motor cortex stroke. The third experiment compares the two strokes. The results indicate permanent occlusion mice suffer great impairments, and a larger injury, than temporarily occluded animals. The mice with the largest insults were most impaired. Mice make an excellent behavioural and genetic model for studying motor system stroke. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Cerebrovascular disease -- Animal models en
dc.subject Cerebrovascular disease -- Complications en
dc.subject Cerebrovascular disease -- Research -- Methodology en
dc.subject Dissertations, Academic en
dc.title A mouse model for studying stroke induced impairments, recovery, and compensation in the motor cortex en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience

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