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Perinatal experience alters brain development and functional recovery after cerebral injury in rats

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author Gibb, Robbin Lynn
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-03-23T17:55:56Z
dc.date.available 2007-03-23T17:55:56Z
dc.date.issued 2004
dc.identifier.uri http://hdl.handle.net/10133/13
dc.description xxi, 221 leaves : ill. ; 28 cm. en
dc.description.abstract Brain damage in the first week of life is behaviorally and anatomically devastating for a rat. I investigated the use of pre- and/or postnatal experience as interventions that might improve the outcomes in rats with postnatal day 4 (P4) frontal cortex lesions. Prenatal maternal tactile stimulation or maternal complex housing facilitated recovery in P4 lesion animals and produced changes in brain organization. Post-lesion tactile stimulation also was found to be beneficial possibly via experience dependent changes in FGF-2 expression. Levels of FGF-2 were increased in both skin and brain after tactile stimulation and correlated with behavioral and anatomical changes. Direct post-lesion administration of FGF-2 had similar effects. These results are the first demonstration that prenatal experience can be prophylactic for postnatal brain injury and that behavioral experience can act on brain organization via enhanced trophic factor expression originating in skin. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2004 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Brain -- Wounds and injuries -- Research en
dc.subject Dissertations, Academic en
dc.subject Brain damage -- Research en
dc.subject Rats -- Physiology en
dc.title Perinatal experience alters brain development and functional recovery after cerebral injury in rats en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience
dc.degree.level Doctor of Philosophy
dc.degree.level PhD
dc.degree.discipline Neuroscience
dc.organization University of Lethbridge
dc.librarysymbol ALU
dc.degree.field Arts and Science
dc.degree.subfield Sciences


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