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The aging hippocampus : a multilevel analysis in the rat

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dc.contributor.advisor Sutherland, Robert en
dc.contributor.author Driscoll, Ira
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-03-23T17:55:51Z
dc.date.available 2007-03-23T17:55:51Z
dc.date.issued 2005
dc.identifier.uri http://hdl.handle.net/10133/12
dc.description iii, 236 leaves : ill. (some col.) ; 29 cm. en
dc.description.abstract The purpose of the current thesis was twofold: (1) to examine various factors that might be contributing to age-related learning and memory deficits specifically related to the hippocampus, and (2) to validate our rat model of aging, employing a multilevel analysis. We found age-related deficits on both spatial and non-spatial hippocampus-dependent taks that were accompanied by structural alterations observed in vivo (volune, but not neuronal metabolic function) and post mortem (neuronal density and neurogenesis, but not synaptic or mitochondrial density). Furthermore, our results suggest that the observed hippocampal structural changes, named decreased volume and neurogenesis, predict learning and memory deficits, and both can be accounted for by neurogenic reduction. In addition, the above-mentioned pattern of age-related deficits closely resembles that seen in humans, suggesting the present rat version of aging to be a very useful model for investigating hippocampal aging in humans. en
dc.format pdf
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Brain -- Aging -- Research en
dc.subject Memory -- Research en
dc.subject Hippocampus (Brain) -- Physiology -- Research en
dc.subject Rats as laboratory animals en
dc.title The aging hippocampus : a multilevel analysis in the rat en
dc.type Electronic Thesis or Dissertation en
dc.publisher.faculty Arts and Science
dc.publisher.department Neuroscience en
dc.degree.name Doctor of Philosophy (Neuroscience)
dc.degree.grantor University of Lethbridge
dc.degree.level Doctoral (Ph.D)
dc.degree.level PH.D, Neuroscience
dc.degree.discipline Neuroscience
dc.organization University of Lethbridge
dc.librarysymbol ALU
dc.degree.field Arts and Science
dc.degree.subfield Sciences

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