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Recovery of function after cingulate cortex injury in rats

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dc.contributor.advisor Kolb, Bryan
dc.contributor.author Gonzalez, Claudia L. R.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2007-04-25T14:40:50Z
dc.date.available 2007-04-25T14:40:50Z
dc.date.issued 2000
dc.identifier.uri http://hdl.handle.net/10133/118
dc.description ix, 111 leaves : ill. ; 29 cm. en
dc.description.abstract The current studies investigate the behavioral and anatomical changes after lesions at different ages of the cingulate cortex. Rats received lesions of the posterior cingulate cortex (PCing) or the anterior and posterior cingulate cortex (Total) at: postnatal day 4 (P4); day 10 (P10), or in adulthood (P120). Rats were trained in the Morris water maze, the Whishaw reaching task, conditioned taste aversion (CTA), and their activity was monitored over 48 hours. The general finding was a significant behavioral recovery on P10 animals regardless the size of the lesion. This recovery was associated with an increase in dendritic arborization in P10 animals with the PCing removed and a partial regeneration of the midline tissue in the Total P10 animals. These results suggest that damage to the cingulate cortex at P10 is associated with substantial behavioral and anatomical plasticity and that removal of the frontal midline tissue stimulates a regenerative process in more posterior cortex that does not occur otherwise. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2000 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Prefrontal cortex -- Physiology en
dc.subject Prefrontal cortex -- Wounds and injuries en
dc.subject Rats as laboratory animals en
dc.subject Neurobiology en
dc.title Recovery of function after cingulate cortex injury in rats en
dc.type Thesis en
dc.publisher.faculty Arts and Science
dc.publisher.department Department of Neuroscience

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