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Browsing University Archives by Author "Kovalchuk, Igor"

Browsing University Archives by Author "Kovalchuk, Igor"

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  • Zemp, Franz Joseph; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008Arts and ScienceDepartment of Biological Sciences, 2008)
    Bystander effects are traditionally known as a phenomenon whereby unexposed cells exhibit the molecular symptoms of stress exposure when adjacent or nearby cells are traversed by ionizing radiation. However, the realm of ...
  • Pepper, Jordan Tan; University of Lethbridge. Faculty of Arts and Science. (Lethbridge, Alta : University of Lethbridge, Dept. of Biological SciencesArts and ScienceDepartment of Biological Sciences, 2015)
    Cell penetrating peptides (CPPs) are short 8-30 amino acid polypeptides that are able to transit across the semi-permeable plasma membrane of living cells, and deliver bound cargoes to the cytoplasm and other subcellular ...
  • Wickersham, Stephanie (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2012Arts and ScienceDepartment of Biological Sciences, 2012)
    DNA double strand breaks (DSBs) are primarily repaired in eukaryotic cells by two different mechanisms – non-homologous end joining (NHEJ) or homologous recombination (HR). In mammalian somatic cells the balance between ...
  • Filkowski, Jody; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, 2004Arts and ScienceDepartment of Biological Sciences, 2004)
    Resistance (R) genes, a key factor in determining the resistance of plants, have been shown often to be highly allelic entities existing in duplicated regions of the genome. This characteristic suggests that R-gene acquisition ...
  • Greer, Michael S.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008Arts and ScienceDepartment of Biological Sciences, 2008)
    Triticum aestivum is of major importance both nutritionally and economically globally. Traditional breeding mechanisms have been unsuccessful at keeping pace with the increasing demand for better yielding and more resilient ...
  • Matsuoka, Aki; University of Lethbridge. Faculty of Arts and Science. (Lethbridge, Alta : University of Lethbridge, Dept. of Biological SciencesArts and ScienceDepartment of Biological Sciences, 2015)
    Agrobacterium tumefaciens has been adopted to become a greatest tool for plant genetic engineering. Since Agrobacteria predominantly integrate single copy of the transgene into the nuclear genome, the transgene expression ...
  • Kathiria, Palak; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2006Arts and ScienceDepartment of Biological Sciences, 2006)
    Pathogens are one of the prevalent stresses to plants. Resistance mediated by the resistance genes is efficient mechanism for evading the pathogens. To understand the influence of various biotic and abiotic factors on ...
  • Walz, Paul S (Lethbridge, Alta. : University of Lethbridge, Dept. of Biology, c2011Arts and ScienceDepartment of Biology, 2011)
    Most bacterial infections can be correlated to contamination of consumables such as food and water. Upon contamination, boil water advisories have been ordered to ensure water is safe to consume, despite the evidence that ...
  • Boyko, Oleksandr; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2004Arts and ScienceDepartment of Biological Sciences, 2004)
    The genome of living organisms is constantly subjected to the environmental influences that result in different negative, negligible or positive impacts. The ability to maintain the genome integrity and simultaneously ...
  • Babenko, Olena M.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010Arts and ScienceDepartment of Biological Sciences, 2010)
    Previous findings showed that mild chronic restraint stress causes motor impairments in rats. These behavioural impairments might be related to molecular changes in brain areas that regulate motor functions, such as the ...
  • MacMillan, Trevor; University of Lethbridge. Faculty of Arts and Science. (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological SciencesArts and ScienceDepartment of Biological Sciences, 2014)
    To address the limitations of conventional nuclear transformation I have developed a peptide based gene delivery system to genetically manipulate the genomes of plant cell mitochondria and plastids. Plant organelle targeting ...
  • Sidler, Corinne (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences.Faculty of Arts and ScienceDepartment of Biological Sciences, 2014-10-03)
    Aging is associated with the functional decline of organs, and results in age-dependent differences in stress-sensitivity. Younger animals are more sensitive to mutagenic insults than adults, whereas in plants, the transition ...
  • Bilichak, Andriy (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological SciencesArts and ScienceDepartment of Biological Sciences, 2013)
    Significant alterations in the environmental conditions can have pronounced effects on plant genome stability. Recent evidence argues for a global involvement of the components of epigenetic modules in the regulation of ...
  • Kathiria, Palak; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, 2010Arts and ScienceDepartment of Biological Sciences, 2010)
    [No abstract available]
  • Babenko, Olena M.; University of Lethbridge. Faculty of Arts and Science. (Lethbridge, Alta. : University of Lethbridge, Dept. of NeuroscienceArts and ScienceDepartment of Neuroscience, 2015)
    Recent human and animal studies indicate that stressful experiences in utero may have long-term consequences on the future mental wellbeing of the offspring across several generations. Epigenetic mechanisms, such as microRNA ...
  • Migicovsky, Zoë (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2012Arts and ScienceDepartment of Biological Sciences, 2012)
    Abiotic stresses are one of the major limiting factors of plant growth and thus crop productivity. Exposure to these stresses, including temperature and UV, cause physiological and epigenetic changes in plants. Such ...
  • Ilnytskyy, Yaroslav; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005Arts and ScienceDepartment of Biological Sciences, 2005)
    In this work we studied various aspects of DNA repair in plants, focusing mainly on point mutation repair and its interconnection with double-strand break repair. We were using transgenic point mutation and recombination ...
  • Boyko, Oleksandr; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008Arts and ScienceBiological Sciences, 2008)
    Homologous recombination represents a DNA repair pathway. Its role in a plant cell is not limited to double strand break repair. It also extends to genome evolution via rearranging of DNA sequences, and has an important ...

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