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Browsing University Archives by Author "Kolb, Bryan"

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Browsing University Archives by Author "Kolb, Bryan"

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  • Gonzalez, Claudia L. R.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2004Arts and ScienceDepartment of Neuroscience, 2004)
    This thesis investigates the behavioural and anatomical correlates of recovery from motor cortex damage in rats. The effectiveness of behavioural, pharmacological, and regenerative treatments was investigated using models ...
  • Comeau, Wendy L.; University of Lethbridge. Faculty of Arts and Science. (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2007Arts and ScienceDepartment of Neuroscience, 2007)
    The effects of experience on developing and mature prefrontal brain circuitry and behaviour were investigated in rats using Ritalin, complex housing, and learning as tools. The results showed that Ritalin altered prefrontal ...
  • Richards, Sonja (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2011Arts and ScienceDepartment of Neuroscience, 2011)
    This thesis examines both behavioral and anatomical effects of prenatal exposure of Valproic Acid (VPA) on Long Evans rats. Tactile stimulation (TS) is then used to investigate its’ effect on remediating any abnormalities ...
  • Waite, Wendy Lou; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003Arts and ScienceDepartment of Neuroscience, 2003)
    This thesis examined the role of exogenous basic fibroblast growth factor (FGF-2) in stimulating recovery after early cortical injury. Rats with medial prefrontal cortex (MFC), posterior parietal cortex (PPC), or sham ...
  • Monfils, Marie-H.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Department of Psychology and Neuroscience, 2005Arts and ScienceDepartment of Neuroscience, 2005)
    Basic fibroblast growth factor (FGF-2) is a trophic molecule involved in a number of functions within the central nervous system (CNS), including a prominent role in the regulation of CNS responses to injury. Prior studies ...
  • Rowntree, Sharon R.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1995Arts and ScienceDepartment of Psychology, 1995)
    Basic fibroblast growth factor (bFGF) has been implicated in the brain's trophic response to injury. This thesis examined the effects of endogenous bFGF on brain plasticity and recovery of behavioral function following ...
  • Halliwell, Celeste I.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003Arts and ScienceDepartment of Neuroscience, 2003)
    Early cortical injury has been attributed to the consequential effects of various factors, such as alcohol, drug addiction, smoking, and inadequate nutrient intakes during periods of pregnancy and lactation, or delivery ...
  • van Waes, Linda T. A; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Deptartment of Neuroscience, 2008Arts and ScienceNeuroscience, 2009)
    This thesis examined how pharmacological treatment and cortical injury during development affects brain plasticity. Rats were given either a low dose of perinatal fluoxetine or a mild postnatal day 7 Hypoxic‐Ischemic (HI) ...
  • Goldsbury, Robin Paulette; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007Arts and ScienceDepartment of Neuroscience, 2007)
    The current work explores the behavioural and anatomical consequences of unilateral neonatal bulbectomy (OBX) in male and female rats at postnatal day 1 (PI) and P10. In adulthood the animals underwent a battery of motor ...
  • Himmler, Brett T.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2011Arts and ScienceDepartment of Neuroscience, 2011)
    The influence of play behavior on the brain was investigated through plasticity and metaplasticity methodology. Regions in both cortical and sub-cortical areas were investigated. Animals in both studies either experienced ...
  • Raza, Sarah (Lethbridge, Alta. : University of Lethbridge, Dept. of NeuroscienceArts and ScienceDepartment of Neuroscience, 2015)
    Autism is a behaviorally defined neurodevelopmental disorder characterized by qualitative impairments in social interaction, communication, and aberrant repetitive behaviors. Behavioral phenotyping in laboratory animals ...
  • Witt-Lajeunesse, Alane; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2001Arts and ScienceDepartment of Neuroscience, 2001)
    Maximizing recovery of function after brain injury is the goal for many neuroscientists and rehabilitation medicine professional alike. To further elucidate the neural mechanisms underlying compensatory changes in brain ...
  • Kovalchuk, Anna; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of NeuroscienceArts and ScienceDepartment of Neuroscience, 2015)
    Based on the most recent estimates by the Canadian Cancer Society, two in five Canadians will develop cancer in their lifetimes. There is mounting evidence that anti-cancer radiation and chemotherapy cause central nervous ...
  • Hastings, Erica; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003Arts and ScienceDepartment of Neuroscience, 2003)
    This thesis focuses on the effects of pharmacological and environmental interventions following perinatal prefrontal cortex lesions. Rats given postnatal day 3 medial prefrontal cortex lesions were provided with one of the ...
  • Gibb, Robbin L.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2001Arts and ScienceDepartment of Neuroscience, 2001)
    The current work explores the therapeutic potential of experiential treatments for enhancing functional recovery and anatomical change after early brain damage. Normal rats and rats with perinatal cortical lesions (P2 or ...
  • Himmler, Brett T.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of NeuroscienceArts and ScienceDepartment of Neuroscience, 2015)
    In laboratory rats, juvenile play behavior has been shown to influence the development of the medial prefrontal cortex (mPFC) and the experience of interacting with multiple partners has been shown to influence the orbital ...
  • Day, Morgan M.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Facutly or Arts and Science, 2005Arts and ScienceDepartment of Neuroscience, 2005)
    Large neocortical lesions, such as hemidecortication, are detrimental for motor and cognitive skills. This thesis investigates the effect of age at the time of lesion on functional outcome. Attempts were then made to improve ...
  • Dallison, Agnes; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1999Arts and ScienceDepartment of Neuroscience, 1999)
    Previous work has shown that removal of the midline frontal cortex at seven to ten days of age is followed by recovery of function correlated with apparent spontaneous generation of new tissue in the lesion cavity. The ...
  • Muhammad, Arif; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2011Arts and ScienceDepartment of Neuroscience, 2011)
    The influence of experience during brain development was investigated on juvenile behavior, adult amphetamine sensitization, and neuronal structural plasticity in rats. Two experiential factors (i.e., tactile stimulation ...
  • Williams, Preston T.J.A.; University of Lethbridge, Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Department of NeuroscienceArts and ScienceDepartment of Neuroscience, 2009)
    In Canada, every ten minutes someone will have a stroke injury to the brain. According to the Heart and Stroke Foundation of Canada 15% of the patients will die and only 10% of patients will recover normal behaviour ...

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