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Browsing by Subject "Rats as laboratory animals"

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Browsing by Subject "Rats as laboratory animals"

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  • Spanswick, Simon; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2010Arts and ScienceDepartment of Neuroscience, 2010)
    Long-term adrenalectomy (ADX) results in a specific loss of dentate gyrus granule cells in the hippocampus of adult rats, occurring over a period of weeks to months. This loss of granule cells results in cognitive deficits ...
  • Driscoll, Ira; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005Arts and ScienceNeuroscience, 2005)
    The purpose of the current thesis was twofold: (1) to examine various factors that might be contributing to age-related learning and memory deficits specifically related to the hippocampus, and (2) to validate our rat model ...
  • Molina, Leonardo A (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2012Arts and ScienceDepartment of Neuroscience, 2012)
    NMDA receptor antagonists such as Ketamine and PCP are potent psychoactive drugs used recreationally. This class of drug induces a number of phenomena in humans similar to those associated with schizophrenia including ...
  • Gonzalez, Claudia L. R.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2004Arts and ScienceDepartment of Neuroscience, 2004)
    This thesis investigates the behavioural and anatomical correlates of recovery from motor cortex damage in rats. The effectiveness of behavioural, pharmacological, and regenerative treatments was investigated using models ...
  • Richards, Sonja (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2011Arts and ScienceDepartment of Neuroscience, 2011)
    This thesis examines both behavioral and anatomical effects of prenatal exposure of Valproic Acid (VPA) on Long Evans rats. Tactile stimulation (TS) is then used to investigate its’ effect on remediating any abnormalities ...
  • Waite, Wendy Lou; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003Arts and ScienceDepartment of Neuroscience, 2003)
    This thesis examined the role of exogenous basic fibroblast growth factor (FGF-2) in stimulating recovery after early cortical injury. Rats with medial prefrontal cortex (MFC), posterior parietal cortex (PPC), or sham ...
  • Monfils, Marie-H.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Department of Psychology and Neuroscience, 2005Arts and ScienceDepartment of Neuroscience, 2005)
    Basic fibroblast growth factor (FGF-2) is a trophic molecule involved in a number of functions within the central nervous system (CNS), including a prominent role in the regulation of CNS responses to injury. Prior studies ...
  • Rowntree, Sharon R.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1995Arts and ScienceDepartment of Psychology, 1995)
    Basic fibroblast growth factor (bFGF) has been implicated in the brain's trophic response to injury. This thesis examined the effects of endogenous bFGF on brain plasticity and recovery of behavioral function following ...
  • Hardy, Jared C.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007Arts and ScienceDepartment of Neuroscience, 2007)
    Conventional cylinder test measures have limited sensitivity in determining hemiparkinson rat forelimb use asymmetry and approximating substantia nigra (SN) dopaminergic neuron loss. This thesis investigates which cylinder ...
  • Spanswick, Simon; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005Arts and ScienceDepartment of Neuroscience, 2005)
    Different events usually contain similar elements that can contribute to interference during memory encoding and retrieval. The hippocampus (HPC), a structure that is critically involved in some forms of memory, has been ...
  • Halliwell, Celeste; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003Arts and ScienceDepartment of Neuroscience, 2003)
    Early cortical injury has been attributed to the consequential effects of various factors, such as alcohol, drug addiction, smoking, and inadequate nutrient intakes during periods of pregnancy and lactation, or delivery ...
  • Melvin, Neal; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008Arts and ScienceNeuroscience, 2008)
    Adult neurogenesis is a fundamental feature of mammalian nervous systems. Curiously, neurogenesis in the dentate gyrus is typically regarded as homogenous. This thesis challenges that view, and reports the discovery and ...
  • van Waes, Linda T. A; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Deptartment of Neuroscience, 2008Arts and ScienceNeuroscience, 2009)
    This thesis examined how pharmacological treatment and cortical injury during development affects brain plasticity. Rats were given either a low dose of perinatal fluoxetine or a mild postnatal day 7 Hypoxic‐Ischemic (HI) ...
  • Goldsbury, Robin Paulette; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007Arts and ScienceDepartment of Neuroscience, 2007)
    The current work explores the behavioural and anatomical consequences of unilateral neonatal bulbectomy (OBX) in male and female rats at postnatal day 1 (PI) and P10. In adulthood the animals underwent a battery of motor ...
  • Xie, Jeanne Yan (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2013Arts and ScienceDepartment of Neuroscience, 2013)
    This study sought to determine whether the DG, CA3, and CA1 regions contain uniformly excitable populations and test the hypothesis that rapid addition of new, more excitable, granule cells in prepubescence results in a ...
  • Himmler, Brett T; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2011Arts and ScienceDepartment of Neuroscience, 2011)
    The influence of play behavior on the brain was investigated through plasticity and metaplasticity methodology. Regions in both cortical and sub-cortical areas were investigated. Animals in both studies either experienced ...
  • Hastings, Erica; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003Arts and ScienceDepartment of Neuroscience, 2003)
    This thesis focuses on the effects of pharmacological and environmental interventions following perinatal prefrontal cortex lesions. Rats given postnatal day 3 medial prefrontal cortex lesions were provided with one of the ...
  • Lowings, Michael D; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010Arts and ScienceDepartment of Biological Sciences, 2010)
    Stroke is one of the most common, and damaging, neurological afflictions. Stroke causes widespread and variable chronic effects, due to the limited regenerative ability of the adult brain. Altered gene expression ...
  • Rakai, Brooke D.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2008Arts and ScienceDepartment of Neuroscience, 2008)
    Stroke outcome is highly variable. Experiments in this thesis test the hypothesis that experience prior to a stroke is an important variable in the manifestation of stroke. Optokinetic tracking was used to evaluate the ...
  • Cardiff, James W (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2012Arts and ScienceDepartment of Neuroscience, 2012)
    Adrenalectomy (ADX) has been shown to cause selective degeneration of granule cells in the dentate gyrus (DG). This occurs due to the reduction of corticosterone (CORT) and behavioural deficit ...