Browsing by Author "Metz, Gerlinde A. S."

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  • Kiss, Douglas A.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta : University of Lethbridge, Dept. of NeuroscienceArts and ScienceDepartment of Neuroscience, 2016)
    Metabolomics provides a method to study the dynamics of cellular function by adopting a systems biology approach to the analysis of small molecule metabolites found in various bio-fluids and tissue locations. Chapters one ...
  • Olson, David M.; Severson, Emily M.; Verstraeten, Barbara S. E.; Ng, Jane W. Y.; McCreary, J. Keiko; Metz, Gerlinde A. S. (M D P I A GArts and ScienceDepartment of NeuroscienceUniversity of AlbertaUniversity of Lethbridge, 2015)
    Preterm birth is a universal health problem that is one of the largest unmet medical needs contributing to the global burden of disease. Adding to its complexity is that there are no means to predict who is at risk when ...
  • Yao, Youli; Robinson, Alexandra M.; Zucchi, Fabiola C. R.; Robbins, Jerrah C.; Babenko, Olena M.; Kovalchuk, Olga; Kovalchuk, Igor; Olson, David M.; Metz, Gerlinde A. S. (BioMed CentralArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeUniversity of Alberta, 2014)
    Abstract Background: Chronic stress is considered to be one of many causes of human preterm birth (PTB), but no direct evidence has yet been provided. Here we show in rats that stress across generations has downstream ...
  • Gerrard, Brietta; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2013Arts and ScienceDepartment of Neuroscience, 2013)
    Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the central nervous system induced in laboratory rodents to mimic human demyelinating diseases such as multiple sclerosis (MS). This thesis ...
  • Erickson, Zachary T. (Lethbridge, Alta. : University of Lethbridge, Dept. of NeuroscienceArts and ScienceDepartment of Neuroscience, 2014)
    This thesis examines the effects of both ancestral stress and postnatal environment on behaviour in male Long Evans rats. We investigated the consequences of maternal exposure to prenatal stress across generations ...
  • Metzler, Megan J.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2010Arts and ScienceDepartment of Neuroscience, 2010)
    Bimanual movement is integral to daily function. As such, it is important to understand factors that influence bimanual performance. Playing the piano was employed to examine bimanual movement. Additionally, the weather ...
  • Chief Moon-Riley, Kathrina; University of Lethbridge. Faculty of Health Sciences (Lethbridge, Alta : University of Lethbridge, Faculty of Health SciencesHealth Sciences, 2017)
    Objective: Examine associations between residential school experiences, adverse childhood experiences, and allostatic load scores among Indigenous students (n = 90) at the University of Lethbridge. Methods: Data for this ...
  • Metzler, Megan J.; Saucier, Deborah M.; Metz, Gerlinde A. S. (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of Ontario Institute of Technology, 2013)
    Aging is associated with deterioration of skilled manual movement. Specifically, aging corresponds with increased reaction time, greater movement duration, segmentation of movement, increased movement variability, and ...
  • Babenko, Olena; Golubov, Andrey; Ilnytskyy, Yaroslav; Kovalchuk, Igor; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of Biological SciencesCanadian Centre for Behavioural NeuroscienceUniversity of LethbridgeUniversity of Calgary, 2012)
    Stress represents a critical influence on motor system function and has been shown to impair movement performance. We hypothesized that stress-induced motor impairments are due to brain-specific changes in miRNA and ...
  • Proft, Juliane; Faraji, Jamshid; Robbins, Jerrah C.; Zucchi, Fabiola C. R.; Zhao, Xiaoxi; Metz, Gerlinde A. S.; Braun, Janice E. A. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of CalgaryUniversity of LethbridgeGolestan University of Medical Sciences, 2011)
    Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra and the aggregation of a-synuclein into Lewy bodies. Existing therapies address motor ...
  • Jadavji, Nafisa M.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008Arts and ScienceDepartment of Neuroscience, 2008)
    Stress is one of the most critical influences on behavior, performance and disease. Recent findings from our laboratory have shown that stress represents a major modulator of motor function in the intact and damaged ...
  • McCreary, J. Keiko; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta : University of Lethbridge, Dept. of NeuroscienceArts and ScienceDepartment of Neuroscience, 2016)
    The stress that our ancestors experienced resonates with us in their stories, and memoires, but does it affect our health? In this thesis, the impact of ancestral stress on offspring was investigated. We hypothesized ...
  • Erickson, Zachary T.; Falkenberg, Erin A.; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    The consumption of artificial food dye (AFD) during childhood and adolescence has been linked to behavioural changes, such as hyperactivity. It is possible that the vulnerability to AFDs is modified by prenatal stress. ...
  • Zucchi, Fabiola C. R.; Yao, Youli; Ilnytskyy, Yaroslav; Robbins, Jerrah C.; Soltanpour, Nasrin; Kovalchuk, Igor; Kovalchuk, Olga; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeUniversity of Mato Grosso State, 2014)
    Prenatal stress (PS) represents a critical variable affecting lifetime health trajectories, metabolic and vascular functions. Beneficial experiences may attenuate the effects of PS and its programming of health outcomes ...
  • Gomez-Lopez, Nardhy; Tanaka, Satomi; Zaeem, Zoya; Metz, Gerlinde A. S.; Olson, David M. (Biomed Central LtdArts and ScienceDepartment of NeuroscienceUniversity of AlbertaUniversity of Lethbridge, 2013)
    Background: Parturition has been widely described as an immunological response; however, it is unknown how this is triggered. We hypothesized that an early event in parturition is an increased responsiveness of ...
  • Zucchi, Fabiola C. R.; Yao, Youli; Ward, Isaac D.; Ilnytskyy, Yaroslav; Olson, David M.; Benzies, Karen; Kovalchuk, Igor; Kovalchuk, Olga; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceDepartment of Biological SciencesUniversity of LethbridgeUniversity of Mato Grosso StateUniversity of AlbertaUniversity of Calgary, 2013)
    The gestational state is a period of particular vulnerability to diseases that affect maternal and fetal health. Stress during gestation may represent a powerful influence on maternal mental health and offspring brain ...
  • Kirkland, Scott; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007Arts and ScienceDepartment of Neuroscience, 2007)
    Stress has been shown to exacerbate cell death and cognitive deficits after ischemic injury in rodents, however, little is known of the effects of stress on motor recovery. The objective of this present thesis is to ...
  • Babenko, Olena M.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010Arts and ScienceDepartment of Biological Sciences, 2010)
    Previous findings showed that mild chronic restraint stress causes motor impairments in rats. These behavioural impairments might be related to molecular changes in brain areas that regulate motor functions, such as the ...
  • Faraji, Jamshid; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta : University of Lethbridge, Faculty of Arts and Science, 2008Arts and ScienceNeuroscience, 2008)
    Stress-related cognitive changes are still a matter of debate. In some particular neuropathological conditions such as focal ischemia, cognitive functions have been shown to be significantly impaired. These conditions, however, ...
  • Faraji, Jamshid; Soltanpour, Nabiollah; Moeeini, Reza; Roudaki, Shabnam; Soltanpour, Nasrin; Abdollahi, Ali-Akbar; Metz, Gerlinde A. S. (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeGolestan University of Medical SciencesBabol University of Medical SciencesAvicenna Institute of Neuroscience, 2014)
    Silent focal ischemic mini infarcts in the brain are thought to cause no clinically overt symptoms. Some populations of hippocampal cells are particularly sensitive to ischemic events, however, rendering hippocampal ...